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FXYD5 (FXYD domain containing ion transport regulator 5)

Identity

Other namesDYSAD
Dysadherin
HSPC113
IWU-1
IWU1
KCT1
OIT2
PRO6241
RIC
UNQ2561
HGNC FXYD5
Location 19q13.12
Location_base_pair Starts at 40337467 and ends at 40352625 bp from pter ( according to hg18-Mar_2006).

DNA/RNA

Transcription 0.9 kb mRNA; 534 bp open reading frame.

Protein

 
  Dysadherin protein consists of 178 amino acids.
Description The deduced amino acid sequence consisted of two hydrophobic regions corresponding to a signal peptide and a transmembrane domain (146-162), a serine-, threonine-, and proline-rich extracellular domain, which is a target for O-glycosylation, anda short cytoplasmic region containing positively charged amino acid residues.
Expression Endothelial cell, T lymphocytes, basal cell of squamous epithelium.
Localisation Cell membrane
Homology The transmembrane domain of dysadherin and mouse RIC especially showed a very high degree of similarity to other ion channels such as Mat-8 chloride channel, phospholemman, which is the major plasma membrane substrate for cAMPdependent protein kinase and protein kinase C, and the subunit of Na, K-ATPase.

Implicated in

Entity Various cancers
Disease Dysadherin, newly identified cell membrane glycoprotein, downregulates E-cadherin and promotes cancer invasion and metastasis. A reverse correlation between dysadherin expression and E-cadherin expression was observed in various cancers. Increased dysadherin expression was correlated with poor prognosis with head and neck squamous cell carcinoma, esophageal carcinoma, gastric carcinoma, colorectal carcinoma, melanoma and so on. Dysadherin expression in epitheloid sarcomas could be a used as powerful diagnostic marker for distinguishing epithelioid sarcomas from malignant rabdoid tumors.
  

External links

Nomenclature
HGNCFXYD5   4029
Entrez_GeneFXYD5  53827  FXYD domain containing ion transport regulator 5
Cards
AtlasFXYD5ID40652ch19q13
GeneCardsFXYD5
EnsemblFXYD5 [Search_View]   ENSG00000089327 [Gene_View]  FXYD5 [Vega]
GenatlasFXYD5
GeneLynxFXYD5
eGenomeFXYD5
euGene53827
Genomic and cartography
GoldenPathFXYD5  -  19q13.12   chr19:40337467-40352625 +  19q13.12   [Description]    (hg18-Mar_2006)
EnsemblFXYD5 - 19q13.12 [CytoView]
NCBIMapview
OMIMDisease map [OMIM]
HomoloGeneFXYD5
Gene and transcription
GenbankAA044211 [ ENTREZ ]
GenbankAA296696 [ ENTREZ ]
GenbankAB072911 [ ENTREZ ]
GenbankAF161462 [ ENTREZ ]
GenbankAF177940 [ ENTREZ ]
RefSeqNM_014164 [ SRS ]    NM_014164 [ ENTREZ ]
RefSeqNM_144779 [ SRS ]    NM_144779 [ ENTREZ ]
RefSeqAC_000062 [ SRS ]    AC_000062 [ ENTREZ ]
RefSeqAC_000151 [ SRS ]    AC_000151 [ ENTREZ ]
RefSeqNC_000019 [ SRS ]    NC_000019 [ ENTREZ ]
RefSeqNT_011109 [ SRS ]    NT_011109 [ ENTREZ ]
RefSeqNW_001838494 [ SRS ]    NW_001838494 [ ENTREZ ]
RefSeqNW_927206 [ SRS ]    NW_927206 [ ENTREZ ]
CCDSFXYD5 CCDS - NCBI
AceViewFXYD5 AceView - NCBI
UnigeneHs.333418 [ SRS ]    Hs.333418 [ NCBI ]     HS333418 [ spliceNest ]
Fast-db10727 (alternative variants)
Protein : pattern, domain, 3D structure
SwissProtQ8IWS1 [ SRS]    Q8IWS1 [ EXPASY ]     Q8IWS1 [ INTERPRO ]     Q8IWS1 [ UNIPROT ] Q8IWS1 [ VarSplice ]
PrositePS01310 FXYD [ SRS ]    PS01310 FXYD [ Expasy ]
InterproIPR000272 Ion-transport_regulator_FXYD [ SRS ]    IPR000272 Ion-transport_regulator_FXYD [ EBI ]
CluSTrQ8IWS1
PfamPF02038 ATP1G1_PLM_MAT8 [ SRS ]    PF02038 ATP1G1_PLM_MAT8 [ Sanger ]    pfam02038 [ NCBI-CDD ]
BlocksQ8IWS1
HPRD09448
Protein Interaction databases
DIPQ8IWS1
IntActQ8IWS1
Polymorphism : SNP, mutations, diseases
OMIM606669    [ map ]   
GENECLINICS606669
SNPFXYD5 [dbSNP-NCBI]  
SNPNM_014164 [SNP-NCI]  
SNPNM_144779 [SNP-NCI]  
SNPFXYD5 [GeneSNPs - Utah]  FXYD5] [HGBASE - SRS]
HAPMAPFXYD5 [HAPMAP]  
HGMDFXYD5
Genetic AssociationFXYD5
CDC HuGEFXYD5
General knowledge
Family BrowserFXYD5 [UCSC Family Browser]
SOURCENM_014164
SOURCENM_144779
SMDHs.333418
SAGEHs.333418
GOactin binding [Amigo]  actin binding
GOion channel activity [Amigo]  ion channel activity
GOion transport [Amigo]  ion transport
GOmembrane [Amigo]  membrane
GOintegral to membrane [Amigo]  integral to membrane
GOmicrovillus biogenesis [Amigo]  microvillus biogenesis
GOcadherin binding [Amigo]  cadherin binding
GOnegative regulation of calcium-dependent cell-cell adhesion [Amigo]  negative regulation of calcium-dependent cell-cell adhesion
PubGeneFXYD5
TreeFamFXYD5
CTD53827 [Comparative ToxicoGenomics Database]
Other databases
Probes
ProbeFXYD5 Related clones (RZPD - Berlin)
PubMed
PubMed19 Pubmed reference(s) in Entrez

Bibliography

Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis.
Ino Y, Gotoh M, Sakamoto M, Tsukagoshi K, Hirohashi S.
Proc Natl Acad Sci USA. 2002; 99(1): 365-70.
PMID 11756660
 
Prognostic significance of dysadherin expression in advanced colorectal carcinoma.
Aoki S, Shimamura T, Shibata T, Nakanishi Y, Moriya Y, Sato Y, Kitajima M, Sakamoto M, Hirohashi S.
Br J Cancer. 2003; 88(5): 726-32.
PMID 12618882
 
Cell adhesion system and human cancer morphogenesis.
Hirohashi S, Kanai Y.
Cancer Sci. 2003; 94(7): 575-81. (Review)
PMID 12841864
 
Dysadherin: expression and clinical significance in thyroid carcinoma.
Sato H, Ino Y, Miura A, Abe Y, Sakai H, Ito K, Hirohashi S.
J Clin Endocrinol Metab. 2003; 88(9): 4407-12.
PMID 12970317
 
Dysadherin overexpression in pancreatic ductal adenocarcinoma reflects tumor aggressiveness: relationship to E-cadherin expression.
Shimamura T, Sakamoto M, Ino Y, Sato Y, Shimada K, Kosuge T, Sekihara H, Hirohashi S.
J Clin Oncol. 2003; 21(4): 659-67.
PMID 12586803
 
Aberrant O-glycosylation inhibits stable expression of dysadherin, a carcinoma-associated antigen, and facilitates cell-cell adhesion.
Tsuiji H, Takasaki S, Sakamoto M, Irimura T, Hirohashi S.
Glycobiology. 2003; 13(7): 521-7.
PMID 12672699
 
Prognostic significance of dysadherin expression in tongue cancer: immunohistochemical analysis of 91 cases.
Nakanishi Y, Akimoto S, Sato Y, Kanai Y, Sakamoto M, Hirohashi S.
Appl Immunohistochem Mol Morphol. 2004; 12(4): 323-8.
PMID 15536331
 
Prognostic significance of dysadherin expression in esophageal squamous cell carcinoma.
Shimada Y, Hashimoto Y, Kan T, Kawamura J, Okumura T, Soma T, Kondo K, Teratani N, Watanabe G, Ino Y, Sakamoto M, Hirohashi S, Imamura M.
Oncology. 2004; 67(1): 73-80.
PMID 15459499
 
Clinical significance of dysadherin expression in gastric cancer patients.
Shimada Y, Yamasaki S, Hashimoto Y, Ito T, Kawamura J, Soma T, Ino Y, Nakanishi Y, Sakamoto M, Hirohashi S, Imamura M.
Clin Cancer Res. 2004; 10(8): 2818-23.
PMID 15102690
 
Dysadherin expression facilitates cell motility and metastatic potential of human pancreatic cancer cells.
Shimamura T, Yasuda J, Ino Y, Gotoh M, Tsuchiya A, Nakajima A, Sakamoto M, Kanai Y, Hirohashi S.
Cancer Res. 2004; 64(19): 6989-95.
PMID 15466191
 
Prognostic significance of dysadherin expression in cervical squamous cell carcinoma.
Wu D, Qiao Y, Kristensen GB, Li S, Troen G, Holm R, Nesland JM, Suo Z.
Pathol Oncol Res. 2004; 10(4): 212-8.
PMID 15619642
 
Establishment of two cell lines from human gastric scirrhous carcinoma that possess the potential to metastasize spontaneously in nude mice.
Yanagihara K, Tanaka H, Takigahira M, Ino Y, Yamaguchi Y, Toge T, Sugano K, Hirohashi S.
Cancer Sci. 2004; 95(7): 575-82.
PMID 15245593
 
Clinicopathologic significance of dysadherin expression in cutaneous malignant melanoma: immunohistochemical analysis of 115 patients.
Nishizawa A, Nakanishi Y, Yoshimura K, Sasajima Y, Yamazaki N, Yamamoto A, Hanada K, Kanai Y, Hirohashi S.
Cancer. 2005; 103(8): 1693-700.
PMID 15751018
 
Prognostic significance of dysadherin expression in patients with non-small cell lung cancer.
Tamura M, Ohta Y, Tsunezuka Y, Matsumoto I, Kawakami K, Oda M, Watanabe G.
J Thorac Cardiovasc Surg. 2005; 130(3): 740-5.
PMID 16153922
 
Expression patterns of dysadherin and E-cadherin in lymph node metastases of colorectal carcinoma.
Batistatou A, Charalabopoulos AK, Scopa CD, Nakanishi Y, Kappas A, Hirohashi S, Agnantis NJ, Charalabopoulos K.
Virchows Arch. 2006; 448(6): 763-7.
PMID 16570180
 
Prognostic significance of dysadherin expression in epithelioid sarcoma and its diagnostic utility in distinguishing epithelioid sarcoma from malignant rhabdoid tumor.
Izumi T, Oda Y, Hasegawa T, Nakanishi Y, Iwasaki H, Sonobe H, Goto H, Kusakabe H, Takahira T, Kobayashi C, Kawaguchi K, Saito T, Yamamoto H, Tamiya S, Iwamoto Y, Tsuneyoshi M.
Mod Pathol. 2006; 19(6): 820-31.
PMID 16557275
 
Dysadherin expression in head and neck squamous cell carcinoma: association with lymphangiogenesis and prognostic significance.
Kyzas PA, Stefanou D, Batistatou A, Agnantis NJ, Nakanishi Y, Hirohashi S, Charalabopoulos K.
Am J Surg Pathol. 2006; 30(2): 185-93.
PMID 16434892
 
Chemokine (C-C motif) ligand 2 mediates the prometastatic effect of dysadherin in human breast cancer cells.
Nam JS, Kang MJ, Suchar AM, Shimamura T, Kohn EA, Michalowska AM, Jordan VC, Hirohashi S, Wakefield LM.
Cancer Res. 2006; 66(14): 7176-84.
PMID 16849564
 
Expression of dysadherin and E-cadherin in trophoblastic tissue in normal and abnormal pregnancies.
Batistatou A, Makrydimas G, Zagorianakou N, Zagorianakou P, Nakanishi Y, Agnantis NJ, Hirohashi S, Charalabopoulos K.
Placenta. 2007; 28(5-6): 590-2.
PMID 17084448
 
In breast carcinoma dysadherin expression is correlated with invasiveness but not with E-cadherin.
Batistatou A, Peschos D, Tsanou H, Charalabopoulos A, Nakanishi Y, Hirohashi S, Agnantis NJ, Charalabopoulos K.
Br J Cancer. 2007; 96(9): 1404-8.
PMID 17437014
 
Nuclear targeting of the growth hormone receptor results in dysregulation of cell proliferation and tumorigenesis.
Conway-Campbell BL, Wooh JW, Brooks AJ, Gordon D, Brown RJ, Lichanska AM, Chin HS, Barton CL, Boyle GM, Parsons PG, Jans DA, Waters MJ.
Proc Natl Acad Sci U S A. 2007; 104(33): 13331-6.
PMID 17690250
 
Dysadherin expression as a significant prognostic factor and as a determinant of histologic features in synovial sarcoma: special reference to its inverse relationship with E-cadherin expression.
Izumi T, Oda Y, Hasegawa T, Nakanishi Y, Kawai A, Sonobe H, Takahira T, Kobayashi C, Yamamoto H, Tamiya S, Hirohashi S, Iwamoto Y, Tsuneyoshi M.
Am J Surg Pathol. 2007; 31(1): 85-94.
PMID 17197923
 
Dysadherin: a new player in cancer progression.
Nam JS, Hirohashi S, Wakefield LM.
Cancer Lett. 2007; 255(2): 161-9. (Review)
PMID 17442482
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written07-2008Setsuo Hirohashi
Pathology Division, National Cancer Center Research Institute 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan

Citation

This paper should be referenced as such :
Hirohashi S . FXYD5 (FXYD domain containing ion transport regulator 5). Atlas Genet Cytogenet Oncol Haematol. July 2008 .
URL : http://AtlasGeneticsOncology.org/Genes/FXYD5ID40652ch19q13.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun Nov 9 19:41:05 2008


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