GAS7 (growth arrest-specific 7)

Identity

Other names	KIAA0394
HGNC	GAS7
Location	17p13
Location_base_pair	Starts at 9754651 and ends at 9803491 bp from pter ( according to hg18-Mar_2006).

DNA/RNA

Description	genomic sequence 167 kb; 14 exons
Transcription	8 kb mRNA; various splicings in the mouse

Protein

Description

412 aa

Expression

in quiescent/terminally differenciated cells, like other GAS (herien the name Growth Arrest-Specific); selective expression in growth-arrested fibroblasts; GAS7 is predominantly expressed in the brain (in particular, in the mouse, in Purkinje cells of the cerebellum, at lower level in other tissues such as the heart and the testes); gas7 expression is associated with neurite formation (and overproduction of gas7 in neuroblastoma cells promotes neurite-like outgrowth) which suggests that GAS7 may have a role in promoting, and possibly maintaining, maturation and morphological differentiation of cerebellar neurons

Implicated in

Entity	treatment-related acute non lymphocytic leukemia with t(11;17)(q23;p13)
Disease	only one case: a 13-year-old boy, with a M4 ANLL and a karyotype with an apparent del(11)(q23) (finally proved to be in reality a cryptic t(11;17)(q23;p13)); four months later the patient died; other cases of t(11;17)(q23;p13) have been described but the involvement of GAS7 has not been proved
Hybrid/Mutated Gene	5' MLL-3' GAS7; breakpoint in MLL intron 8, in MLL bcr; GAS7 breakpoint upstream of exon 1; fusion of mLL exon 7 or exon 8 to GAS7 exon 2

External links

	Nomenclature
HGNC	GAS7   4169
Entrez_Gene	GAS7  8522  growth arrest-specific 7
	Cards
Atlas	GAS7ID257
GeneCards	GAS7
Ensembl	GAS7 [Search_View]   ENSG00000007237 [Gene_View]  GAS7 [Vega]
Genatlas	GAS7
GeneLynx	GAS7
eGenome	GAS7
euGene	8522
	Genomic and cartography
GoldenPath	GAS7  -  17p13   chr17:9754651-9803491 -  17p13.1   [Description]    (hg18-Mar_2006)
Ensembl	GAS7 - 17p13.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	GAS7
	Gene and transcription
Genbank	AB007854 [ ENTREZ ]
Genbank	AB209030 [ ENTREZ ]
Genbank	AF231997 [ ENTREZ ]
Genbank	AJ224876 [ ENTREZ ]
Genbank	AK057761 [ ENTREZ ]
RefSeq	NM_001130831 [ SRS ]    NM_001130831 [ ENTREZ ]
RefSeq	NM_003644 [ SRS ]    NM_003644 [ ENTREZ ]
RefSeq	NM_201432 [ SRS ]    NM_201432 [ ENTREZ ]
RefSeq	NM_201433 [ SRS ]    NM_201433 [ ENTREZ ]
RefSeq	AC_000060 [ SRS ]    AC_000060 [ ENTREZ ]
RefSeq	AC_000149 [ SRS ]    AC_000149 [ ENTREZ ]
RefSeq	NC_000017 [ SRS ]    NC_000017 [ ENTREZ ]
RefSeq	NT_010718 [ SRS ]    NT_010718 [ ENTREZ ]
RefSeq	NW_001838403 [ SRS ]    NW_001838403 [ ENTREZ ]
RefSeq	NW_926584 [ SRS ]    NW_926584 [ ENTREZ ]
CCDS	GAS7 CCDS - NCBI
AceView	GAS7 AceView - NCBI
Unigene	Hs.462214 [ SRS ]    Hs.462214 [ NCBI ]     HS462214 [ spliceNest ]
Fast-db	3948 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O60861 [ SRS]    O60861 [ EXPASY ]     O60861 [ INTERPRO ]     O60861 [ UNIPROT ] O60861 [ VarSplice ]
Prosite	PS50133 FCH [ SRS ]    PS50133 FCH [ Expasy ]
Prosite	PS01159 WW_DOMAIN_1 [ SRS ]    PS01159 WW_DOMAIN_1 [ Expasy ]
Prosite	PS50020 WW_DOMAIN_2 [ SRS ]    PS50020 WW_DOMAIN_2 [ Expasy ]
Interpro	IPR001060 Cdc15_Fes_CIP4 [ SRS ]    IPR001060 Cdc15_Fes_CIP4 [ EBI ]
Interpro	IPR001202 WW_Rsp5_WWP [ SRS ]    IPR001202 WW_Rsp5_WWP [ EBI ]
CluSTr	O60861
Pfam	PF00611 FCH [ SRS ]    PF00611 FCH [ Sanger ]    pfam00611 [ NCBI-CDD ]
Pfam	PF00397 WW [ SRS ]    PF00397 WW [ Sanger ]    pfam00397 [ NCBI-CDD ]
Smart	SM00055 FCH [EMBL]
Smart	SM00456 WW [EMBL]
Blocks	O60861
PDB	2YSH [ SRS ]    2YSH [ PdbSum ],   2YSH [ IMB ]   2YSH [ RSDB ]
HPRD	16011
	Protein Interaction databases
DIP	O60861
IntAct	O60861
	Polymorphism : SNP, mutations, diseases
OMIM	603127    [ map ]
GENECLINICS	603127
SNP	GAS7 [dbSNP-NCBI]
SNP	NM_001130831 [SNP-NCI]
SNP	NM_003644 [SNP-NCI]
SNP	NM_201432 [SNP-NCI]
SNP	NM_201433 [SNP-NCI]
SNP	GAS7 [GeneSNPs - Utah]  GAS7] [HGBASE - SRS]
HAPMAP	GAS7 [HAPMAP]
COSMIC	GAS7 [Somatic mutation (COSMIC-CGP-Sanger)]
TICdb	GAS7 [Translocation breakpoints In Cancer]
HGMD	GAS7
Genetic Association	GAS7
CDC HuGE	GAS7
	General knowledge
Family Browser	GAS7 [UCSC Family Browser]
SOURCE	NM_001130831
SOURCE	NM_003644
SOURCE	NM_201432
SOURCE	NM_201433
SMD	Hs.462214
SAGE	Hs.462214
GO	transcription factor activity [Amigo]  transcription factor activity
GO	protein binding [Amigo]  protein binding
GO	cytoplasm [Amigo]  cytoplasm
GO	cell cycle arrest [Amigo]  cell cycle arrest
GO	multicellular organismal development [Amigo]  multicellular organismal development
GO	nervous system development [Amigo]  nervous system development
GO	cell differentiation [Amigo]  cell differentiation
PubGene	GAS7
TreeFam	GAS7
CTD	8522 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	Cancer Cytogenetics (Bari)
Probe	GAS7 Related clones (RZPD - Berlin)
	PubMed
PubMed	11 Pubmed reference(s) in Entrez

Bibliography

gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation.

Ju YT, Chang AC, She BR, Tsaur ML, Hwang HM, Chao CC, Cohen SN, Lin-Chao S

Proceedings of the National Academy of Sciences of the United States of America. 1998 ; 95 (19) : 11423-11428.

PMID 9736752

Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors.

Megonigal MD, Cheung NK, Rappaport EF, Nowell PC, Wilson RB, Jones DH, Addya K, Leonard DG, Kushner BH, Williams TM, Lange BJ, Felix CA

Proceedings of the National Academy of Sciences of the United States of America. 2000 ; 97 (6) : 2814-2819.

PMID 10706619

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	06-2000	Jean-Loup Huret

Citation

This paper should be referenced as such :

Huret JL . GAS7 (growth arrest-specific 7). Atlas Genet Cytogenet Oncol Haematol. June 2000 . URL : http://AtlasGeneticsOncology.org/Genes/GAS7ID257.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sun Nov 9 19:41:07 2008