GASC1 (Gene amplified in squamous cell carcinoma 1)

Identity

Other names	KIAA0780
HGNC	JMJD2C
Location	9p23-24
Location_base_pair	Starts at 6747654 and ends at 7165648 bp from pter ( according to hg18-Mar_2006).

DNA/RNA

Note	At least 22 exons spanning approximately 417194 bps. 4239 bp mRNA; coding sequence: 3171 bp

Protein

Description

1056 ammino acid; possesses PHD domain

Implicated in

Entity	amplification and overexpression in cell lines derived from esophageal squamous cell carcinomas

External links

	Nomenclature
HGNC	JMJD2C   17071
Entrez_Gene	JMJD2C  23081  jumonji domain containing 2C
	Cards
Atlas	GASC1ID432
GeneCards	JMJD2C
Ensembl	JMJD2C [Search_View]   ENSG00000107077 [Gene_View]  JMJD2C [Vega]
Genatlas	JMJD2C
GeneLynx	JMJD2C
eGenome	JMJD2C
euGene	23081
	Genomic and cartography
GoldenPath	JMJD2C  -     chr9:6747654-7165648 +  9p24-p23   [Description]    (hg18-Mar_2006)
Ensembl	JMJD2C - 9p24-p23 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	JMJD2C
	Gene and transcription
Genbank	AB018323 [ ENTREZ ]
Genbank	AB037901 [ ENTREZ ]
Genbank	AF085959 [ ENTREZ ]
Genbank	AI017056 [ ENTREZ ]
Genbank	AK304095 [ ENTREZ ]
RefSeq	NM_015061 [ SRS ]    NM_015061 [ ENTREZ ]
RefSeq	AC_000052 [ SRS ]    AC_000052 [ ENTREZ ]
RefSeq	AC_000141 [ SRS ]    AC_000141 [ ENTREZ ]
RefSeq	NC_000009 [ SRS ]    NC_000009 [ ENTREZ ]
RefSeq	NT_008413 [ SRS ]    NT_008413 [ ENTREZ ]
RefSeq	NW_001839149 [ SRS ]    NW_001839149 [ ENTREZ ]
RefSeq	NW_924062 [ SRS ]    NW_924062 [ ENTREZ ]
CCDS	JMJD2C CCDS - NCBI
AceView	JMJD2C AceView - NCBI
Unigene	Hs.709425 [ SRS ]    Hs.709425 [ NCBI ]     HS709425 [ spliceNest ]
Fast-db	2099 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q9H3R0 [ SRS]    Q9H3R0 [ EXPASY ]     Q9H3R0 [ INTERPRO ]     Q9H3R0 [ UNIPROT ] Q9H3R0 [ VarSplice ]
Prosite	PS51184 JMJC [ SRS ]    PS51184 JMJC [ Expasy ]
Prosite	PS51183 JMJN [ SRS ]    PS51183 JMJN [ Expasy ]
Prosite	PS50304 TUDOR [ SRS ]    PS50304 TUDOR [ Expasy ]
Prosite	PS01359 ZF_PHD_1 [ SRS ]    PS01359 ZF_PHD_1 [ Expasy ]
Prosite	PS50016 ZF_PHD_2 [ SRS ]    PS50016 ZF_PHD_2 [ Expasy ]
Interpro	IPR013129 TF_JmjC [ SRS ]    IPR013129 TF_JmjC [ EBI ]
Interpro	IPR003347 TF_JmjC_AAH [ SRS ]    IPR003347 TF_JmjC_AAH [ EBI ]
Interpro	IPR003349 TF_JmjN [ SRS ]    IPR003349 TF_JmjN [ EBI ]
Interpro	IPR002999 Tudor [ SRS ]    IPR002999 Tudor [ EBI ]
Interpro	IPR001965 Znf_PHD [ SRS ]    IPR001965 Znf_PHD [ EBI ]
CluSTr	Q9H3R0
Pfam	PF02373 JmjC [ SRS ]    PF02373 JmjC [ Sanger ]    pfam02373 [ NCBI-CDD ]
Pfam	PF02375 JmjN [ SRS ]    PF02375 JmjN [ Sanger ]    pfam02375 [ NCBI-CDD ]
Smart	SM00558 JmjC [EMBL]
Smart	SM00545 JmjN [EMBL]
Smart	SM00249 PHD [EMBL]
Smart	SM00333 TUDOR [EMBL]
Blocks	Q9H3R0
HPRD	12016
	Protein Interaction databases
DIP	Q9H3R0
IntAct	Q9H3R0
	Polymorphism : SNP, mutations, diseases
OMIM	605469    [ map ]
GENECLINICS	605469
SNP	JMJD2C [dbSNP-NCBI]
SNP	NM_015061 [SNP-NCI]
SNP	JMJD2C [GeneSNPs - Utah]  JMJD2C] [HGBASE - SRS]
HAPMAP	JMJD2C [HAPMAP]
COSMIC	JMJD2C [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	JMJD2C
Genetic Association	JMJD2C
CDC HuGE	JMJD2C
	General knowledge
Family Browser	JMJD2C [UCSC Family Browser]
SOURCE	NM_015061
SMD	Hs.709425
SAGE	Hs.709425
Enzyme	1.14.11.- [ Enzyme-Expasy ]   1.14.11.- [ Enzyme-SRS ]   1.14.11.- [ IntEnz-EBI ]   1.14.11.- [ BRENDA ]   1.14.11.- [ KEGG ]   1.14.11.- [ WIT ]
GO	molecular_function [Amigo]  molecular_function
GO	nucleic acid binding [Amigo]  nucleic acid binding
GO	iron ion binding [Amigo]  iron ion binding
GO	protein binding [Amigo]  protein binding
GO	cellular_component [Amigo]  cellular_component
GO	nucleus [Amigo]  nucleus
GO	transcription [Amigo]  transcription
GO	regulation of transcription, DNA-dependent [Amigo]  regulation of transcription, DNA-dependent
GO	biological_process [Amigo]  biological_process
GO	zinc ion binding [Amigo]  zinc ion binding
GO	oxidoreductase activity [Amigo]  oxidoreductase activity
GO	chromatin modification [Amigo]  chromatin modification
GO	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Amigo]  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO	metal ion binding [Amigo]  metal ion binding
GO	oxidation reduction [Amigo]  oxidation reduction
PubGene	JMJD2C
TreeFam	JMJD2C
CTD	23081 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	JMJD2C Related clones (RZPD - Berlin)
	PubMed
PubMed	11 Pubmed reference(s) in Entrez

Bibliography

Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines.

Yang ZQ, Imoto I, Fukuda Y, Pimkhaokham A, Shimada Y, Imamura M, Sugano S, Nakamura Y, Inazawa J

Cancer research. 2000 ; 60 (17) : 4735-4739.

PMID 10987278

A novel amplicon at 9p23 - 24 in squamous cell carcinoma of the esophagus that lies proximal to GASC1 and harbors NFIB.

Yang ZQ, Imoto I, Pimkhaokham A, Shimada Y, Sasaki K, Oka M, Inazawa J

Japanese journal of cancer research : Gann. 2001 ; 92 (4) : 423-428.

PMID 11346465

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	12-2002	Zeng-Quan Yang
		University of Michigan, Department of Radiation Oncology, RM. 7121 CCGC, 1500 E Med Ctr. Dr., Ann Arbor, MI 48109-0948, USA

Citation

This paper should be referenced as such :

Yang ZQ . GASC1 (Gene amplified in squamous cell carcinoma 1). Atlas Genet Cytogenet Oncol Haematol. December 2002 . URL : http://AtlasGeneticsOncology.org/Genes/GASC1ID432.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sun Nov 9 19:41:08 2008