Atlas of Genetics and Cytogenetics in Oncology and Haematology

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AANAT (aralkylamine N-acetyltransferase)

Identity

Alias_namesarylalkylamine N-acetyltransferase
Alias_symbol (synonym)SNAT
Other aliasDSPS
HGNC (Hugo) AANAT
LocusID (NCBI) 15
Atlas_Id 52492
Location 17q25.1  [Link to chromosome band 17q25]
Location_base_pair Starts at 76453351 and ends at 76470117 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AGAP1 (2q37.2) / AANAT (17q25.1)AGAP1 2q37.2 / AANAT 17q25.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;17)(q37;q25) AGAP1/AANAT

External links

Nomenclature
HGNC (Hugo)AANAT   19
Cards
Entrez_Gene (NCBI)AANAT  15  aralkylamine N-acetyltransferase
AliasesDSPS; SNAT
GeneCards (Weizmann)AANAT
Ensembl hg19 (Hinxton)ENSG00000129673 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000129673 [Gene_View]  ENSG00000129673 [Sequence]  chr17:76453351-76470117 [Contig_View]  AANAT [Vega]
ICGC DataPortalENSG00000129673
TCGA cBioPortalAANAT
AceView (NCBI)AANAT
Genatlas (Paris)AANAT
WikiGenes15
SOURCE (Princeton)AANAT
Genetics Home Reference (NIH)AANAT
Genomic and cartography
GoldenPath hg38 (UCSC)AANAT  -     chr17:76453351-76470117 +  17q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AANAT  -     17q25.1   [Description]    (hg19-Feb_2009)
GoldenPathAANAT - 17q25.1 [CytoView hg19]  AANAT - 17q25.1 [CytoView hg38]
ImmunoBaseENSG00000129673
Mapping of homologs : NCBIAANAT [Mapview hg19]  AANAT [Mapview hg38]
OMIM600950   
Gene and transcription
Genbank (Entrez)AA084486 AB593119 AI819939 AY055827 BC069434
RefSeq transcript (Entrez)NM_001088 NM_001166579
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AANAT
Cluster EST : UnigeneHs.431417 [ NCBI ]
CGAP (NCI)Hs.431417
Alternative Splicing GalleryENSG00000129673
Gene ExpressionAANAT [ NCBI-GEO ]   AANAT [ EBI - ARRAY_EXPRESS ]   AANAT [ SEEK ]   AANAT [ MEM ]
Gene Expression Viewer (FireBrowse)AANAT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)15
GTEX Portal (Tissue expression)AANAT
Human Protein AtlasENSG00000129673-AANAT [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16613   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16613  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16613
Splice isoforms : SwissVarQ16613
Catalytic activity : Enzyme2.3.1.87 [ Enzyme-Expasy ]   2.3.1.872.3.1.87 [ IntEnz-EBI ]   2.3.1.87 [ BRENDA ]   2.3.1.87 [ KEGG ]   
PhosPhoSitePlusQ16613
Domaine pattern : Prosite (Expaxy)GNAT (PS51186)   
Domains : Interpro (EBI)Acyl_CoA_acyltransferase    GNAT_dom   
Domain families : Pfam (Sanger)Acetyltransf_1 (PF00583)   
Domain families : Pfam (NCBI)pfam00583   
Conserved Domain (NCBI)AANAT
DMDM Disease mutations15
Blocks (Seattle)AANAT
SuperfamilyQ16613
Human Protein Atlas [tissue]ENSG00000129673-AANAT [tissue]
Peptide AtlasQ16613
HPRD02974
IPIIPI00003354   IPI00954083   
Protein Interaction databases
DIP (DOE-UCLA)Q16613
IntAct (EBI)Q16613
FunCoupENSG00000129673
BioGRIDAANAT
STRING (EMBL)AANAT
ZODIACAANAT
Ontologies - Pathways
QuickGOQ16613
Ontology : AmiGOaralkylamine N-acetyltransferase activity  aralkylamine N-acetyltransferase activity  aralkylamine N-acetyltransferase activity  aralkylamine N-acetyltransferase activity  arylamine N-acetyltransferase activity  protein binding  cytoplasm  cytosol  cytosol  N-terminal protein amino acid acetylation  circadian rhythm  circadian rhythm  circadian rhythm  response to light stimulus  photoperiodism  response to zinc ion  melatonin biosynthetic process  melatonin biosynthetic process  melatonin biosynthetic process  melatonin biosynthetic process  response to insulin  response to cytokine  response to prostaglandin E  indolalkylamine biosynthetic process  response to copper ion  perinuclear region of cytoplasm  response to corticosterone  response to calcium ion  cellular response to cAMP  14-3-3 protein binding  
Ontology : EGO-EBIaralkylamine N-acetyltransferase activity  aralkylamine N-acetyltransferase activity  aralkylamine N-acetyltransferase activity  aralkylamine N-acetyltransferase activity  arylamine N-acetyltransferase activity  protein binding  cytoplasm  cytosol  cytosol  N-terminal protein amino acid acetylation  circadian rhythm  circadian rhythm  circadian rhythm  response to light stimulus  photoperiodism  response to zinc ion  melatonin biosynthetic process  melatonin biosynthetic process  melatonin biosynthetic process  melatonin biosynthetic process  response to insulin  response to cytokine  response to prostaglandin E  indolalkylamine biosynthetic process  response to copper ion  perinuclear region of cytoplasm  response to corticosterone  response to calcium ion  cellular response to cAMP  14-3-3 protein binding  
Pathways : KEGGTryptophan metabolism   
NDEx NetworkAANAT
Atlas of Cancer Signalling NetworkAANAT
Wikipedia pathwaysAANAT
Orthology - Evolution
OrthoDB15
GeneTree (enSembl)ENSG00000129673
Phylogenetic Trees/Animal Genes : TreeFamAANAT
HOGENOMQ16613
Homologs : HomoloGeneAANAT
Homology/Alignments : Family Browser (UCSC)AANAT
Gene fusions - Rearrangements
Fusion : MitelmanAGAP1/AANAT [2q37.2/17q25.1]  [t(2;17)(q37;q25)]  
Fusion PortalAGAP1 2q37.2 AANAT 17q25.1 LUSC
Fusion : QuiverAANAT
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAANAT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AANAT
dbVarAANAT
ClinVarAANAT
1000_GenomesAANAT 
Exome Variant ServerAANAT
ExAC (Exome Aggregation Consortium)ENSG00000129673
GNOMAD BrowserENSG00000129673
Varsome BrowserAANAT
Genetic variants : HAPMAP15
Genomic Variants (DGV)AANAT [DGVbeta]
DECIPHERAANAT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAANAT 
Mutations
ICGC Data PortalAANAT 
TCGA Data PortalAANAT 
Broad Tumor PortalAANAT
OASIS PortalAANAT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAANAT  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DAANAT
Mutations and Diseases : HGMDAANAT
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AANAT
DgiDB (Drug Gene Interaction Database)AANAT
DoCM (Curated mutations)AANAT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AANAT (select a term)
intoGenAANAT
Cancer3DAANAT(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600950   
Orphanet
DisGeNETAANAT
MedgenAANAT
Genetic Testing Registry AANAT
NextProtQ16613 [Medical]
TSGene15
GENETestsAANAT
Target ValidationAANAT
Huge Navigator AANAT [HugePedia]
snp3D : Map Gene to Disease15
BioCentury BCIQAANAT
ClinGenAANAT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD15
Chemical/Pharm GKB GenePA24366
Clinical trialAANAT
Miscellaneous
canSAR (ICR)AANAT (select the gene name)
DataMed IndexAANAT
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAANAT
EVEXAANAT
GoPubMedAANAT
iHOPAANAT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:30:35 CET 2019
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