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AATK (apoptosis associated tyrosine kinase)

Identity

Alias_symbol (synonym)AATYK
KIAA0641
LMTK1
LMR1
AATYK1
PPP1R77
Other aliasp35BP
HGNC (Hugo) AATK
LocusID (NCBI) 9625
Atlas_Id 43100
Location 17q25.3  [Link to chromosome band 17q25]
Location_base_pair Starts at 81117296 and ends at 81131948 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AATK (17q25.3) / LAMA5 (20q13.33)AATK (17q25.3) / USP32 (17q23.1)LAMA5 (20q13.33) / AATK (17q25.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(17;17)(q23;q25) AATK/USP32
t(17;20)(q25;q13) AATK/LAMA5
t(17;20)(q25;q13) LAMA5/AATK

External links

Nomenclature
HGNC (Hugo)AATK   21
Cards
Entrez_Gene (NCBI)AATK  9625  apoptosis associated tyrosine kinase
AliasesAATYK; AATYK1; LMR1; LMTK1; 
PPP1R77; p35BP
GeneCards (Weizmann)AATK
Ensembl hg19 (Hinxton)ENSG00000181409 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000181409 [Gene_View]  ENSG00000181409 [Sequence]  chr17:81117296-81131948 [Contig_View]  AATK [Vega]
ICGC DataPortalENSG00000181409
TCGA cBioPortalAATK
AceView (NCBI)AATK
Genatlas (Paris)AATK
WikiGenes9625
SOURCE (Princeton)AATK
Genetics Home Reference (NIH)AATK
Genomic and cartography
GoldenPath hg38 (UCSC)AATK  -     chr17:81117296-81131948 -  17q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AATK  -     17q25.3   [Description]    (hg19-Feb_2009)
GoldenPathAATK - 17q25.3 [CytoView hg19]  AATK - 17q25.3 [CytoView hg38]
Genome Data Viewer NCBIAATK [Mapview hg19]  
OMIM605276   
Gene and transcription
Genbank (Entrez)AB014541 AK094931 AK131395 AK131529 AK309099
RefSeq transcript (Entrez)NM_001080395 NM_004920
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AATK
Alternative Splicing GalleryENSG00000181409
Gene ExpressionAATK [ NCBI-GEO ]   AATK [ EBI - ARRAY_EXPRESS ]   AATK [ SEEK ]   AATK [ MEM ]
Gene Expression Viewer (FireBrowse)AATK [ Firebrowse - Broad ]
GenevisibleExpression of AATK in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9625
GTEX Portal (Tissue expression)AATK
Human Protein AtlasENSG00000181409-AATK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZMQ8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZMQ8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZMQ8
Splice isoforms : SwissVarQ6ZMQ8
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ6ZMQ8
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)   
Domains : Interpro (EBI)Kinase-like_dom_sf    LMTK1_c    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam07714   
Conserved Domain (NCBI)AATK
DMDM Disease mutations9625
SuperfamilyQ6ZMQ8
Human Protein Atlas [tissue]ENSG00000181409-AATK [tissue]
Peptide AtlasQ6ZMQ8
HPRD05591
IPIIPI00797912   IPI00784827   IPI00883789   IPI00742193   
Protein Interaction databases
DIP (DOE-UCLA)Q6ZMQ8
IntAct (EBI)Q6ZMQ8
FunCoupENSG00000181409
BioGRIDAATK
STRING (EMBL)AATK
ZODIACAATK
Ontologies - Pathways
QuickGOQ6ZMQ8
Ontology : AmiGOprotein kinase activity  protein serine/threonine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  cellular_component  protein phosphorylation  brain development  biological_process  integral component of membrane  peptidyl-tyrosine autophosphorylation  perinuclear region of cytoplasm  
Ontology : EGO-EBIprotein kinase activity  protein serine/threonine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  cellular_component  protein phosphorylation  brain development  biological_process  integral component of membrane  peptidyl-tyrosine autophosphorylation  perinuclear region of cytoplasm  
NDEx NetworkAATK
Atlas of Cancer Signalling NetworkAATK
Wikipedia pathwaysAATK
Orthology - Evolution
OrthoDB9625
GeneTree (enSembl)ENSG00000181409
Phylogenetic Trees/Animal Genes : TreeFamAATK
HOGENOMQ6ZMQ8
Homologs : HomoloGeneAATK
Homology/Alignments : Family Browser (UCSC)AATK
Gene fusions - Rearrangements
Fusion : MitelmanAATK/LAMA5 [17q25.3/20q13.33]  
Fusion : MitelmanAATK/USP32 [17q25.3/17q23.1]  
Fusion : MitelmanLAMA5/AATK [20q13.33/17q25.3]  
Fusion : QuiverAATK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAATK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AATK
dbVarAATK
ClinVarAATK
1000_GenomesAATK 
Exome Variant ServerAATK
GNOMAD BrowserENSG00000181409
Varsome BrowserAATK
Genetic variants : HAPMAP9625
Genomic Variants (DGV)AATK [DGVbeta]
DECIPHERAATK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAATK 
Mutations
ICGC Data PortalAATK 
TCGA Data PortalAATK 
Broad Tumor PortalAATK
OASIS PortalAATK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAATK  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DAATK
Mutations and Diseases : HGMDAATK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutaselect AATK
DgiDB (Drug Gene Interaction Database)AATK
DoCM (Curated mutations)AATK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AATK (select a term)
intoGenAATK
Cancer3DAATK (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605276   
Orphanet
DisGeNETAATK
MedgenAATK
Genetic Testing Registry AATK
NextProtQ6ZMQ8 [Medical]
TSGene9625
GENETestsAATK
Open Targets GeneticsENSG00000181409  [validation]
snp3D : Map Gene to Disease9625
BioCentury BCIQAATK
ClinGenAATK
Clinical trials, drugs, therapy
Protein Interactions : CTD9625
Pharm GKB GenePA24370
Clinical trialAATK
Miscellaneous
canSAR (ICR)AATK (select the gene name)
HarmonizomeAATK
DataMed IndexAATK
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAATK
EVEXAATK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sat Jul 11 19:37:22 CEST 2020
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