ABCC2 (ATP binding cassette subfamily C member 2)

2003-02-01 Affiliation

Identity

HGNC

ABCC2

LOCATION

10q24.2

LOCUSID

1244

ALIAS

ABC30,CMOAT,DJS,MRP2,cMRP

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1244
MIM: 601107
HGNC: 53
Ensembl: ENSG00000023839

Variants:

dbSNP: 1244
ClinVar: 1244
TCGA: ENSG00000023839
COSMIC: ABCC2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000023839	ENST00000647814	Q92887
ENSG00000023839	ENST00000648324	A0A3B3IS94
ENSG00000023839	ENST00000648523	A0A3B3ITG8
ENSG00000023839	ENST00000648689	A0A3B3IRZ2
ENSG00000023839	ENST00000649493	A0A3B3IRU4
ENSG00000023839	ENST00000649932	A0A3B3IRZ2

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
ABC transporters	KEGG	ko02010
ABC transporters	KEGG	hsa02010
Bile secretion	KEGG	ko04976
Bile secretion	KEGG	hsa04976
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
ABC-family proteins mediated transport	REACTOME	R-HSA-382556
Platinum drug resistance	KEGG	ko01524
Platinum drug resistance	KEGG	hsa01524
Antifolate resistance	KEGG	ko01523
Antifolate resistance	KEGG	hsa01523

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA10204	tenofovir	Chemical	ClinicalAnnotation	associated		PD	17083032, 19400747, 25485598, 26287941, 26535588, 26807589, 31619748
PA10251	atazanavir	Chemical	ClinicalAnnotation	associated		PD	26287941
PA10804	imatinib	Chemical	ClinicalAnnotation	associated		PD	30237583
PA10810	pemetrexed	Chemical	ClinicalAnnotation	associated		PD
PA128406956	fluorouracil	Chemical	ClinicalAnnotation	associated		PD	23314736
PA131285527	oxaliplatin	Chemical	ClinicalAnnotation	associated		PD	23314736
PA132595336	calcein	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK		22027652
PA133888799	Organ Transplantation	Disease	ClinicalAnnotation	associated	PK		25163792
PA133950441	hmg coa reductase inhibitors	Chemical	Pathway	associated
PA134308647	rosuvastatin	Chemical	VariantAnnotation	associated	PK		30100615
PA142650384	pitavastatin	Chemical	ClinicalAnnotation	associated	PK		23007012
PA143485705	antiepileptics	Chemical	ClinicalAnnotation, Literature, MultilinkAnnotation	associated	PK	PD	21449672, 21799461, 22188362, 22256867, 22630058, 23697249, 24567120, 24624913, 25155934, 27816260
PA146123005	talinolol	Chemical	ClinicalAnnotation	associated			18334920
PA151958383	Gastrointestinal Stromal Tumors	Disease	ClinicalAnnotation	associated		PD	30237583
PA164712708	Drugs For Treatment Of Tuberculosis	Chemical	ClinicalAnnotation	associated		PD	31648372
PA164713176	Platinum compounds	Chemical	Pathway	associated			19525887
PA164748728	mycophenolic acid	Chemical	ClinicalAnnotation	associated	PK		25163792, 28624888
PA164760843	deferasirox	Chemical	ClinicalAnnotation	associated	PK	PD	25348619, 26403473
PA164925725	Toxic liver disease	Disease	ClinicalAnnotation	associated		PD	31648372
PA165110775	SN-38	Chemical	Pathway	associated
PA165817016	Kidney Transplantation	Disease	ClinicalAnnotation	associated	PK		25163792, 28316087, 28624888, 29318894
PA378	NR1I2	Gene	Pathway	associated			21151855
PA443421	Arrhythmias, Cardiac	Disease	ClinicalAnnotation	associated	PK	PD	16330681
PA443434	Arthritis, Rheumatoid	Disease	ClinicalAnnotation	associated		PD	18381794, 27217051
PA443560	Breast Neoplasms	Disease	ClinicalAnnotation	associated	PK	PD
PA443622	Carcinoma, Non-Small-Cell Lung	Disease	ClinicalAnnotation	associated		PD	18221820
PA443658	Central Nervous System Infections	Disease	ClinicalAnnotation	associated	PK		29873816
PA443756	Colonic Neoplasms	Disease	ClinicalAnnotation	associated		PD	23314736
PA443937	Drug Toxicity	Disease	ClinicalAnnotation	associated	PK	PD	16330681
PA444065	Epilepsy	Disease	ClinicalAnnotation	associated	PK	PD	20216337, 21449672, 21799461, 22188362, 22256867, 22630058, 23252947, 23697249, 24567120, 25155934, 27816260
PA444109	Exanthema	Disease	ClinicalAnnotation	associated		PD	23237922
PA444516	Hypercholesterolemia	Disease	ClinicalAnnotation	associated		PD	29178257
PA444682	Kidney Diseases	Disease	ClinicalAnnotation	associated		PD	17083032, 19400747, 25485598, 26535588, 26807589
PA444756	Leukemia, Lymphoid	Disease	ClinicalAnnotation	associated	PK		23069858, 24241962, 29791011
PA444845	Lymphoma, Non-Hodgkin	Disease	ClinicalAnnotation	associated	PK	PD	16330681
PA444937	Mesothelioma	Disease	ClinicalAnnotation	associated		PD
PA445941	Tuberculosis	Disease	ClinicalAnnotation	associated		PD	31648372
PA446108	Colorectal Neoplasms	Disease	ClinicalAnnotation	associated	PK	PD	18981587
PA446155	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Disease	ClinicalAnnotation	associated	PK	PD	24241962
PA446157	Leukemia, B-Cell, Acute	Disease	ClinicalAnnotation	associated	PK	PD	23222202
PA446432	beta-Thalassemia	Disease	ClinicalAnnotation	associated	PK	PD	25348619, 26403473
PA447230	HIV Infections	Disease	ClinicalAnnotation	associated	PK	PD	17083032, 19400747, 19842932, 22027652, 25485598, 26535588, 26774523, 26807589, 31619748
PA448500	atorvastatin	Chemical	ClinicalAnnotation, Pathway	associated		PD	22186618, 29178257
PA448785	carbamazepine	Chemical	ClinicalAnnotation, Pathway	associated	PK	PD	20216337, 21449672, 21738081, 21799461, 22188362, 22256867, 22630058, 23252947, 23697249, 24567120, 25155934
PA448866	ceftriaxone	Chemical	ClinicalAnnotation	associated	PK		29873816
PA449014	cisplatin	Chemical	ClinicalAnnotation	associated		PD
PA449165	cyclophosphamide	Chemical	ClinicalAnnotation	associated		PD
PA449167	cyclosporine	Chemical	ClinicalAnnotation	associated	PK		25163792, 28624888
PA449383	docetaxel	Chemical	ClinicalAnnotation, Pathway	associated	PK	PD	18294295, 21151855, 23188068
PA449412	doxorubicin	Chemical	ClinicalAnnotation	associated	PK	PD	16330681
PA449441	efavirenz	Chemical	ClinicalAnnotation	associated	PK		26774523
PA449493	erythromycin	Chemical	ClinicalAnnotation	associated	PK
PA450085	irinotecan	Chemical	ClinicalAnnotation, Pathway	associated	PK	PD	18221820, 18981587
PA450163	lamivudine	Chemical	Pathway	associated
PA450198	leucovorin	Chemical	ClinicalAnnotation	associated		PD	23314736
PA450264	lopinavir	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	19842932, 22027652, 26287941
PA450272	lovastatin	Chemical	Pathway	associated
PA450428	methotrexate	Chemical	ClinicalAnnotation, Pathway	associated	PK	PD	18381794, 21317831, 23069858, 23222202, 24241962, 25502615, 27217051, 29791011
PA450732	oxcarbazepine	Chemical	ClinicalAnnotation	associated	PK	PD	21449672, 21799461, 22188362, 22256867, 22630058, 23697249, 24567120, 25155934
PA450761	paclitaxel	Chemical	Pathway	associated			21151855
PA451089	pravastatin	Chemical	ClinicalAnnotation, Pathway	associated	PK		17047488
PA451260	ritonavir	Chemical	ClinicalAnnotation	associated		PD	26287941
PA451363	simvastatin	Chemical	ClinicalAnnotation, Pathway	associated		PD	22186618
PA451578	tacrolimus	Chemical	ClinicalAnnotation	associated	PK		28316087, 29318894
PA451581	tamoxifen	Chemical	ClinicalAnnotation	associated	PK	PD
PA451879	vincristine	Chemical	Pathway	associated
PA7000	sorafenib	Chemical	ClinicalAnnotation	associated		PD	23237922

References

Pubmed ID	Year	Title	Citations
16330681	2005	NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity.	96
19349540	2009	Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.	74
12576456	2003	RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response.	69
15226675	2004	High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1).	69
16385451	2006	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	69
16426233	2006	Role of Nrf2 in the regulation of the Mrp2 (ABCC2) gene.	67
20124171	2010	Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients.	62
19400747	2009	Predictors of kidney tubular dysfunction in HIV-infected patients treated with tenofovir: a pharmacogenetic study.	60
20530282	2010	Pharmacogenetic predictors of adverse events and response to chemotherapy in metastatic colorectal cancer: results from North American Gastrointestinal Intergroup Trial N9741.	58
17534875	2007	Associations of ABCB1, ABCC2, and ABCG2 polymorphisms with irinotecan-pharmacokinetics and clinical outcome in patients with advanced non-small cell lung cancer.	57

Citation

Dessen P

ABCC2 (ATP binding cassette subfamily C member 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/539/abcc2