ABCC4 (ATP binding cassette subfamily C member 4)

2003-11-01  

Identity

HGNC
ABCC4
LOCATION
13q32.1
LOCUSID
10257
ALIAS
MOAT-B,MOATB,MRP4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10257
MIM: 605250
HGNC: 55
Ensembl: ENSG00000125257

Variants:

dbSNP: 10257
ClinVar: 10257
TCGA: ENSG00000125257
COSMIC: ABCC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125257ENST00000536256O15439
ENSG00000125257ENST00000629385O15439
ENSG00000125257ENST00000642524A0A2R8YDG7
ENSG00000125257ENST00000643051A0A2R8Y6V8
ENSG00000125257ENST00000643556A0A2R8Y5Z3
ENSG00000125257ENST00000643842Q8IWU1
ENSG00000125257ENST00000645237O15439
ENSG00000125257ENST00000645532A0A2R8YDC1
ENSG00000125257ENST00000646439O15439

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ABC transportersKEGGko02010
ABC transportersKEGGhsa02010
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Transmembrane transport of small moleculesREACTOMER-HSA-382551
ABC-family proteins mediated transportREACTOMER-HSA-382556
Antifolate resistanceKEGGko01523
Antifolate resistanceKEGGhsa01523

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10005adefovir dipivoxilChemicalPathwayassociated
PA10204tenofovirChemicalClinicalAnnotation, Pathway, VariantAnnotationambiguousPKPD17083032, 17597712, 18398970
PA10227valganciclovirChemicalClinicalAnnotationassociatedPD27402191
PA10804imatinibChemicalClinicalAnnotationassociatedPD23127916
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPKPD19696793
PA151958383Gastrointestinal Stromal TumorsDiseaseClinicalAnnotationassociatedPD23127916
PA164712563BisphosphonatesChemicalClinicalAnnotationassociatedPD
PA164774763latanoprostChemicalClinicalAnnotationassociatedPD25339146
PA165817016Kidney TransplantationDiseaseClinicalAnnotationassociatedPD27402191
PA166163418rucaparibChemicalLabelAnnotationassociated
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPKPD19696793
PA443842DeathDiseaseVariantAnnotationassociatedPD
PA443937Drug ToxicityDiseaseClinicalAnnotationassociatedPKPD19696793
PA444282Glaucoma, Open-AngleDiseaseClinicalAnnotationassociatedPD25339146
PA444370Heart FailureDiseaseClinicalAnnotationassociatedPD26927285
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPKPD19696793
PA445187OsteonecrosisDiseaseClinicalAnnotationassociatedPD
PA446116Inflammatory Bowel DiseasesDiseaseClinicalAnnotationassociatedPKPD20393862
PA446155Precursor Cell Lymphoblastic Leukemia-LymphomaDiseaseClinicalAnnotationassociatedPD25348617
PA446157Leukemia, B-Cell, AcuteDiseaseClinicalAnnotationassociatedPKPD23222202
PA446661Carcinoma, Small CellDiseaseClinicalAnnotationassociatedPD23478653
PA447230HIVDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD16791115, 17083032, 17597712, 18398970
PA448515azathioprineChemicalClinicalAnnotationassociatedPKPD20393862
PA449014cisplatinChemicalClinicalAnnotationassociatedPD23478653
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPKPD19696793
PA449177cytarabineChemicalMultilinkAnnotationassociated26842729
PA449412doxorubicinChemicalClinicalAnnotationassociatedPKPD19696793
PA449719furosemideChemicalClinicalAnnotationassociatedPD26927285
PA450085irinotecanChemicalClinicalAnnotationassociatedPD23478653
PA450163lamivudineChemicalPathwayassociated
PA450379mercaptopurineChemicalClinicalAnnotation, VariantAnnotationassociatedPKPD20393862
PA450428methotrexateChemicalClinicalAnnotation, PathwayassociatedPKPD23222202, 25348617, 25502615
PA451954zidovudineChemicalClinicalAnnotation, PathwayassociatedPK16791115, 22960662

References

Pubmed IDYearTitleCitations
128354122003The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs.104
118567622002The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP.93
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
180455362007Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia.84
126955382003Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5.78
126375262003Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells.69
125239362003Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4).64
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
194007472009Predictors of kidney tubular dysfunction in HIV-infected patients treated with tenofovir: a pharmacogenetic study.60
128834812003Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane.51

Citation

Dessen P

ABCC4 (ATP binding cassette subfamily C member 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/541/abcc4