ABCG2 (ATP binding cassette subfamily G member 2 (Junior blood group))

2003-02-01  

Identity

HGNC
LOCATION
4q22.1
LOCUSID
ALIAS
ABC15,ABCP,BCRP,BCRP1,BMDP,CD338,CDw338,EST157481,GOUT1,MRX,MXR,MXR-1,MXR1,UAQTL1
FUSION GENES

Other Information

Locus ID:

NCBI: 9429
MIM: 603756
HGNC: 74
Ensembl: ENSG00000118777

Variants:

dbSNP: 9429
ClinVar: 9429
TCGA: ENSG00000118777
COSMIC: ABCG2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118777ENST00000237612Q9UNQ0
ENSG00000118777ENST00000237612A0A024RDD4
ENSG00000118777ENST00000503830F8S0F2
ENSG00000118777ENST00000505480F8S0F2
ENSG00000118777ENST00000515655Q9UNQ0
ENSG00000118777ENST00000650821Q9UNQ0
ENSG00000118777ENST00000650821A0A024RDD4

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
ABC transportersKEGGko02010
ABC transportersKEGGhsa02010
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Iron uptake and transportREACTOMER-HSA-917937
MetabolismREACTOMER-HSA-1430728
Abacavir transport and metabolismREACTOMER-HSA-2161522
Abacavir transmembrane transportREACTOMER-HSA-2161517
Antifolate resistanceKEGGko01523
Antifolate resistanceKEGGhsa01523

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10204tenofovirChemicalClinicalAnnotationassociatedPK28462920
PA10804imatinibChemicalClinicalAnnotation, VariantAnnotation, VipGeneassociatedPKPD18981009, 24123600, 24322003, 30713339
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD20530282, 24018773, 24338217
PA130620651anthracyclines and related substancesChemicalVipGeneassociated24021215
PA131285527oxaliplatinChemicalClinicalAnnotationassociatedPD20530282, 24338217
PA131301952gefitinibChemicalClinicalAnnotationassociatedPD17148776, 20035425, 21332310, 25554506
PA133950441hmg coa reductase inhibitorsChemicalLiterature, MultilinkAnnotation, Pathwayassociated25084202
PA134308647rosuvastatinChemicalClinicalAnnotation, DataAnnotation, LabelAnnotation, VipGeneassociatedPKPD19474787, 16784736, 18617601, 19474787, 20130569, 20207952, 20679960, 22331829, 23930675, 25630984, 28322941
PA134865839SLCO1B1GeneDataAnnotationassociated
PA151958383Gastrointestinal Stromal TumorsDiseaseClinicalAnnotationassociatedPD30713339
PA151958596curcuminChemicalVipGeneassociated25587128
PA162372840sunitinibChemicalClinicalAnnotation, VipGeneassociatedPKPD24013576, 25344452, 26244574
PA162372878dasatinibChemicalClinicalAnnotation, VariantAnnotation, VipGeneassociatedPD24322003
PA164712948Opioid anestheticsChemicalClinicalAnnotationassociatedPD30136624
PA164713083Other general anestheticsChemicalClinicalAnnotationassociatedPD30136624
PA164713176Platinum compoundsChemicalPathwayassociated19525887
PA164760843deferasiroxChemicalClinicalAnnotationassociatedPKPD27043265, 27193993, 28346059
PA164924562elacridarChemicalVipGeneassociated
PA165110729rhodamine 123ChemicalVipGeneassociated11559526
PA165110775SN-38ChemicalPathwayassociated
PA165291492pazopanibChemicalMultilinkAnnotationassociated25504632
PA165958345nilotinibChemicalClinicalAnnotation, VariantAnnotation, VipGeneassociatedPD24322003
PA166114961dolutegravirChemicalClinicalAnnotationassociatedPK28858994
PA166131630volatile anestheticsChemicalClinicalAnnotationassociatedPD30136624
PA166154579rs4149056VariantLabelAnnotationassociated
PA166156544rs2231142VariantLabelAnnotationassociated
PA166163418rucaparibChemicalLabelAnnotationassociated
PA166163740apixabanChemicalClinicalAnnotationassociatedPK28678049, 29457840
PA166184498ezetimibe / rosuvastatinChemicalLabelAnnotationassociated
PA378NR1I2GenePathwayassociated21151855
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotationassociatedPD20386493, 24394199, 27217051
PA443459Atrial FibrillationDiseaseClinicalAnnotationassociatedPK28678049, 29457840
PA443557Brain NeoplasmsDiseaseClinicalAnnotationassociatedPK27052877
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPD
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPD18221820
PA443658Central Nervous System InfectionsDiseaseClinicalAnnotationassociatedPK29873816
PA443937Drug ToxicityDiseaseClinicalAnnotationassociatedPD30713339
PA444065EpilepsyDiseaseClinicalAnnotationassociatedPKPD26213157, 27610747, 29791014
PA444101Esophageal NeoplasmsDiseaseVipGeneassociated
PA444318GoutDiseaseClinicalAnnotationassociatedPD26810134, 29341237, 30924126
PA444516HypercholesterolemiaDiseaseClinicalAnnotationassociatedPKPD16784736, 19474787, 20130569, 20207952, 20679960, 23930675, 25630984, 28322941
PA444818Lung NeoplasmsDiseaseClinicalAnnotationassociatedPD17148776, 20035425, 21332310, 25554506
PA445019Myocardial InfarctionDiseaseClinicalAnnotationassociatedPKPD16784736, 19474787, 20130569, 20207952, 20679960, 23930675, 25630984, 28322941
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPKPD24013576, 25344452, 26244574
PA445451PsoriasisDiseaseClinicalAnnotationassociatedPD18256692
PA445601OsteosarcomaDiseaseClinicalAnnotationassociatedPKPD25778468, 29791011
PA445742Stomach NeoplasmsDiseaseVipGeneassociated
PA446108Colorectal NeoplasmsDiseaseClinicalAnnotation, VipGeneassociatedPD20530282, 24018773, 24338217
PA446171Leukemia, Myelogenous, Chronic, BCR-ABL PositiveDiseaseClinicalAnnotationassociatedPD24123600
PA446432beta-ThalassemiaDiseaseClinicalAnnotationassociatedPKPD27043265, 27193993, 28346059
PA447230HIVDiseaseClinicalAnnotationassociatedPKPD23859571, 28462920, 28858994
PA448320allopurinolChemicalClinicalAnnotation, VariantAnnotation, VipGeneassociatedPD26810134, 29341237, 30924126
PA448500atorvastatinChemicalClinicalAnnotation, VipGeneassociatedPKPD19474787
PA448771capecitabineChemicalClinicalAnnotationassociatedPD20530282, 24338217
PA448866ceftriaxoneChemicalClinicalAnnotationassociatedPK29873816
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD
PA449167cyclosporineChemicalVipGeneassociated
PA449212daunorubicinChemicalVipGeneassociated24021215
PA449383docetaxelChemicalPathwayassociated21151855
PA449412doxorubicinChemicalClinicalAnnotation, VipGeneassociatedPD11956086
PA449441efavirenzChemicalClinicalAnnotationassociatedPD23859571
PA449688fluvastatinChemicalClinicalAnnotation, VipGeneassociatedPK19842935
PA449748gemcitabineChemicalClinicalAnnotationassociatedPD
PA450085irinotecanChemicalClinicalAnnotationassociatedPD18221820, 24018773
PA450163lamivudineChemicalPathwayassociated
PA450164lamotrigineChemicalClinicalAnnotationassociatedPKPD26213157, 27610747, 29791014
PA450198leucovorinChemicalClinicalAnnotationassociatedPD20530282, 24018773, 24338217
PA450428methotrexateChemicalClinicalAnnotation, Pathway, VipGeneassociatedPKPD18237272, 18256692, 20386493, 21317831, 25778468, 27217051, 29791011
PA450761paclitaxelChemicalPathwayassociated21151855
PA451089pravastatinChemicalPathway, VipGeneassociated19842935
PA451363simvastatinChemicalClinicalAnnotation, Literature, MultilinkAnnotation, VipGeneassociatedPK19842935, 24598718
PA451547sulfasalazineChemicalClinicalAnnotation, MultilinkAnnotation, VipGeneassociatedPKPD18167504, 24394199, 25872459, 28322941
PA451729topotecanChemicalClinicalAnnotation, VipGeneassociatedPK27052877
PA451954zidovudineChemicalPathwayassociated22960662

References

Pubmed IDYearTitleCitations
160246222005Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic.308
195035972009Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.228
188346262008Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study.221
145768422003Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2).204
195062522009Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout.181
195062522009Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout.181
150444682004The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme.171
124298622002The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.147
208848462010Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors.135
188295472008Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2.128

Citation

Dessen P

ABCG2 (ATP binding cassette subfamily G member 2 (Junior blood group))

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/546/abcg2