ABRAXAS2 (abraxas 2, BRISC complex subunit)

2017-05-01 Affiliation

HGNC

ABRAXAS2

LOCATION

10q26.13

LOCUSID

23172

ALIAS

ABRO1,FAM175B,KIAA0157

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Gene ID	Transcript ID	Uniprot
ENSG00000165660	ENST00000298492	Q15018

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Deubiquitination	REACTOME	R-HSA-5688426
Metalloprotease DUBs	REACTOME	R-HSA-5689901

Not detected

Low

Medium

High

Pubmed ID	Year	Title	Citations
25283148	2014	ABRO1 suppresses tumourigenesis and regulates the DNA damage response by stabilizing p53.	17
26344097	2015	Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function.	14
21195082	2011	Regulation of Abro1/KIAA0157 during myocardial infarction and cell death reveals a novel cardioprotective mechanism for Lys63-specific deubiquitination.	10
27993934	2017	Cell cycle-regulated ubiquitination of tankyrase 1 by RNF8 and ABRO1/BRCC36 controls the timing of sister telomere resolution.	10
30755420	2019	The BRISC deubiquitinating enzyme complex limits hematopoietic stem cell expansion by regulating JAK2 K63-ubiquitination.	2
30854784	2019	FAM175B promotes apoptosis by inhibiting ATF4 ubiquitination in esophageal squamous cell carcinoma.	0

Dessen P

ABRAXAS2 (abraxas 2, BRISC complex subunit)

Atlas Genet Cytogenet Oncol Haematol. 2017-05-01