Identity
HGNC
LOCATION
12q24.11
LOCUSID
ALIAS
ACC-beta,ACC2,ACCB,HACC275
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 32
MIM: 601557
HGNC: 85
Ensembl: ENSG00000076555
Variants:
dbSNP: 32
ClinVar: 32
TCGA: ENSG00000076555
COSMIC: ACACB
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA33744 | PRKAA1 | Gene | Pathway | associated | 22722338 | ||
| PA33745 | PRKAA2 | Gene | Pathway | associated | 22722338 | ||
| PA33746 | PRKAB1 | Gene | Pathway | associated | 22722338 | ||
| PA33747 | PRKAB2 | Gene | Pathway | associated | 22722338 | ||
| PA33751 | PRKAG1 | Gene | Pathway | associated | 22722338 | ||
| PA33752 | PRKAG2 | Gene | Pathway | associated | 22722338 | ||
| PA33753 | PRKAG3 | Gene | Pathway | associated | 22722338 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34939260 | 2022 | Acetyl-coenzyme A carboxylase beta gene polymorphism does not predict cardiovascular risk susceptibility in Chinese type 2 diabetic individuals. | 1 |
| 36111743 | 2022 | ACACB is a novel metabolism-related biomarker in the prediction of response to cetuximab therapy inmetastatic colorectal cancer. | 1 |
| 34939260 | 2022 | Acetyl-coenzyme A carboxylase beta gene polymorphism does not predict cardiovascular risk susceptibility in Chinese type 2 diabetic individuals. | 1 |
| 36111743 | 2022 | ACACB is a novel metabolism-related biomarker in the prediction of response to cetuximab therapy inmetastatic colorectal cancer. | 1 |
| 33957017 | 2021 | Faster lipid β-oxidation rate by acetyl-CoA carboxylase 2 inhibition alleviates high-glucose-induced insulin resistance via SIRT1/PGC-1α in human podocytes. | 7 |
| 34085602 | 2021 | Identification of core gene in obese type 2 diabetes patients using bioinformatics analysis. | 7 |
| 33957017 | 2021 | Faster lipid β-oxidation rate by acetyl-CoA carboxylase 2 inhibition alleviates high-glucose-induced insulin resistance via SIRT1/PGC-1α in human podocytes. | 7 |
| 34085602 | 2021 | Identification of core gene in obese type 2 diabetes patients using bioinformatics analysis. | 7 |
| 29772612 | 2018 | Activity and structure of human acetyl-CoA carboxylase targeted by a specific inhibitor. | 2 |
| 29772612 | 2018 | Activity and structure of human acetyl-CoA carboxylase targeted by a specific inhibitor. | 2 |
| 27693630 | 2017 | Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab. | 43 |
| 28081256 | 2017 | Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells. | 48 |
| 28290443 | 2017 | Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival. | 48 |
| 28768177 | 2017 | Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation. | 136 |
| 29107296 | 2017 | Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants. | 32 |
Citation
Dessen P
ACACB (acetyl-CoA carboxylase beta)
Atlas Genet Cytogenet Oncol Haematol. 2007-12-01
Online version: http://atlasgeneticsoncology.org/gene/49847/acacb
