ACE2 (angiotensin converting enzyme 2)

2003-05-01  

Identity

HGNC
LOCATION
Xp22.2
LOCUSID
ALIAS
ACEH
FUSION GENES

Other Information

Locus ID:

NCBI: 59272
MIM: 300335
HGNC: 13557
Ensembl: ENSG00000130234

Variants:

dbSNP: 59272
ClinVar: 59272
TCGA: ENSG00000130234
COSMIC: ACE2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130234ENST00000252519Q9BYF1
ENSG00000130234ENST00000427411Q9BYF1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Renin-angiotensin systemKEGGko04614
Renin-angiotensin systemKEGGhsa04614
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Metabolism of Angiotensinogen to AngiotensinsREACTOMER-HSA-2022377

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD17473847
PA448780captoprilChemicalClinicalAnnotationassociatedPD17473847

References

Pubmed IDYearTitleCitations
146473842003Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.1336
146473842003Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.1336
321426512020SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.1161
160010712005Angiotensin-converting enzyme 2 protects from severe acute lung failure.531
161665182005Structure of SARS coronavirus spike receptor-binding domain complexed with receptor.448
241729012013Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor.421
321321842020Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2.371
118156272002Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase.322
146709652004A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2.285
157912052005Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2.279

Citation

Dessen P

ACE2 (angiotensin converting enzyme 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/552/ace2