Identity
HGNC
LOCATION
9p22.1
LOCUSID
ALIAS
ALKCDase2,ASAH3L
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 340485
MIM: 613492
HGNC: 23675
Ensembl: ENSG00000177076
Variants:
dbSNP: 340485
ClinVar: 340485
TCGA: ENSG00000177076
COSMIC: ACER2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000177076 | ENST00000340967 | Q5QJU3 |
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36513872 | 2023 | miR-196a-5p Correlates with Chronic Atrophic Gastritis Progression to Gastric Cancer and Induces Malignant Biological Behaviors of Gastric Cancer Cells by Targeting ACER2. | 1 |
| 36513872 | 2023 | miR-196a-5p Correlates with Chronic Atrophic Gastritis Progression to Gastric Cancer and Induces Malignant Biological Behaviors of Gastric Cancer Cells by Targeting ACER2. | 1 |
| 33093451 | 2020 | TIMELESS regulates sphingolipid metabolism and tumor cell growth through Sp1/ACER2/S1P axis in ER-positive breast cancer. | 19 |
| 33093451 | 2020 | TIMELESS regulates sphingolipid metabolism and tumor cell growth through Sp1/ACER2/S1P axis in ER-positive breast cancer. | 19 |
| 29229990 | 2018 | Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2. | 32 |
| 29229990 | 2018 | Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2. | 32 |
| 28294157 | 2017 | Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation. | 21 |
| 28294157 | 2017 | Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation. | 21 |
| 26943039 | 2016 | Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response. | 27 |
| 26943039 | 2016 | Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response. | 27 |
| 24708996 | 2014 | Regulation of alkaline ceramidase activity by the c-Src-mediated pathway. | 2 |
| 24708996 | 2014 | Regulation of alkaline ceramidase activity by the c-Src-mediated pathway. | 2 |
| 20089856 | 2010 | Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2). | 37 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
| 20628055 | 2010 | Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells. | 30 |
Citation
Dessen P
ACER2 (alkaline ceramidase 2)
Atlas Genet Cytogenet Oncol Haematol. 2010-10-01
Online version: http://atlasgeneticsoncology.org/gene/51740/acer2
