ACKR2 (atypical chemokine receptor 2)

2003-06-01  

Identity

HGNC
ACKR2
LOCATION
3p22.1
LOCUSID
1238
ALIAS
CCBP2,CCR10,CCR9,CMKBR9,D6,hD6
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1238
MIM: 602648
HGNC: 1565
Ensembl: ENSG00000144648

Variants:

dbSNP: 1238
ClinVar: 1238
TCGA: ENSG00000144648
COSMIC: ACKR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144648ENST00000422265O00590
ENSG00000144648ENST00000422265A0A024R2X7
ENSG00000144648ENST00000442925O00590
ENSG00000144648ENST00000442925A0A024R2X7
ENSG00000144648ENST00000492609V9GZ70
ENSG00000144648ENST00000493193V9GYB7
ENSG00000144648ENST00000494619V9GYX0
ENSG00000144648ENST00000497921V9GYM0

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
126710492003CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells.84
125942482003Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6.55
176073622007The atypical chemokine receptor D6 suppresses the development of chemically induced skin tumors.51
150845962004beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6.49
124068802003CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking.47
227965822012The chemokine decoy receptor D6 prevents excessive inflammation and adverse ventricular remodeling after myocardial infarction.29
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
187083602008Chemokine decoy receptor d6 plays a negative role in human breast cancer.25
190748852008Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.25
182019742008Multiple roles for the C-terminal tail of the chemokine scavenger D6.18

Citation

Dessen P

ACKR2 (atypical chemokine receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/937/ackr2