ACKR4 (atypical chemokine receptor 4)

2009-08-01  

Identity

HGNC
LOCATION
3q22.1
LOCUSID
ALIAS
CC-CKR-11,CCBP2,CCR-11,CCR10,CCR11,CCRL1,CCX

Other Information

Locus ID:

NCBI: 51554
MIM: 606065
HGNC: 1611
Ensembl: ENSG00000129048

Variants:

dbSNP: 51554
ClinVar: 51554
TCGA: ENSG00000129048
COSMIC: ACKR4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129048ENST00000249887Q9NPB9
ENSG00000129048ENST00000509820H0Y9Z2

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108

References

Pubmed IDYearTitleCitations
167918972006The chemokine receptor CCX-CKR mediates effective scavenging of CCL19 in vitro.41
193838222009Involvement of a novel chemokine decoy receptor CCX-CKR in breast cancer growth, metastasis and patient survival.28
119818102002Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR.23
233414472013β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR.10
242601342013Effect of genetic variants in two chemokine decoy receptor genes, DARC and CCBP2, on metastatic potential of breast cancer.9
231215572013Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR.5
243387202014CCX-CKR expression in colorectal cancer and patient survival.5
305181372018Fluorescently Tagged CCL19 and CCL21 to Monitor CCR7 and ACKR4 Functions.3
234624542013Prognostic impact of atypical chemokine receptor expression in patients with gastric cancer.2
266999092016Endogenous expression of the atypical chemokine receptor CCX-CKR (CCRL1) gene in human embryonic kidney (HEK 293) cells.0

Citation

Dessen P

ACKR4 (atypical chemokine receptor 4)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51003/ackr4