ACP5 (acid phosphatase 5, tartrate resistant)

2003-11-01 Affiliation

Identity

HGNC

ACP5

LOCATION

19p13.2

LOCUSID

ALIAS

HPAP,TRACP5a,TRACP5b,TRAP,TrATPase

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 54
MIM: 171640
HGNC: 124
Ensembl: ENSG00000102575

Variants:

dbSNP: 54
ClinVar: 54
TCGA: ENSG00000102575
COSMIC: ACP5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000102575	ENST00000218758	P13686
ENSG00000102575	ENST00000218758	A0A024R7F8
ENSG00000102575	ENST00000412435	P13686
ENSG00000102575	ENST00000412435	A0A024R7F8
ENSG00000102575	ENST00000589792	K7ESF2
ENSG00000102575	ENST00000590420	K7ES19
ENSG00000102575	ENST00000590832	K7EJD9
ENSG00000102575	ENST00000591319	K7EIP0
ENSG00000102575	ENST00000592828	P13686
ENSG00000102575	ENST00000648477	P13686
ENSG00000102575	ENST00000648477	A0A024R7F8
ENSG00000102575	ENST00000649386	A0A3B3IS75

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Riboflavin metabolism	KEGG	ko00740
Riboflavin metabolism	KEGG	hsa00740
Lysosome	KEGG	ko04142
Lysosome	KEGG	hsa04142
Metabolic pathways	KEGG	hsa01100
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
Rheumatoid arthritis	KEGG	ko05323
Rheumatoid arthritis	KEGG	hsa05323
Metabolism	REACTOME	R-HSA-1430728
Metabolism of vitamins and cofactors	REACTOME	R-HSA-196854
Metabolism of water-soluble vitamins and cofactors	REACTOME	R-HSA-196849
Vitamin B2 (riboflavin) metabolism	REACTOME	R-HSA-196843

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
21217755	2011	Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature.	62
21217752	2011	Genetic deficiency of tartrate-resistant acid phosphatase associated with skeletal dysplasia, cerebral calcifications and autoimmunity.	44
16280328	2006	MCP-1-induced human osteoclast-like cells are tartrate-resistant acid phosphatase, NFATc1, and calcitonin receptor-positive but require receptor activator of NFkappaB ligand for bone resorption.	43
18285546	2008	A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group.	41
12073156	2002	Serum tartrate-resistant acid phosphatase 5b, but not 5a, correlates with other markers of bone turnover and bone mineral density.	20
18421493	2008	Serum levels of TRAP5b, a new bone resorption marker unaffected by renal dysfunction, as a useful marker of cortical bone loss in hemodialysis patients.	20
17997709	2008	A new heterozygous mutation (R714C) of the osteopetrosis gene, pleckstrin homolog domain containing family M (with run domain) member 1 (PLEKHM1), impairs vesicular acidification and increases TRACP secretion in osteoclasts.	15
18221403	2008	Utility of serum tartrate-resistant acid phosphatase (TRACP5b) as a bone resorption marker in patients with chronic kidney disease: independence from renal dysfunction.	15
23604121	2014	ACP5, a direct transcriptional target of FoxM1, promotes tumor metastasis and indicates poor prognosis in hepatocellular carcinoma.	15
15542543	2005	Properties and expression of human tartrate-resistant acid phosphatase isoform 5a by monocyte-derived cells.	14

Citation

Dessen P

ACP5 (acid phosphatase 5, tartrate resistant)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/555/acp5