ACSL4 (acyl-CoA synthetase long chain family member 4)

2007-02-01  

Identity

HGNC
ACSL4
LOCATION
Xq23
LOCUSID
2182
ALIAS
ACS4,FACL4,LACS4,MRX63,MRX68
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2182
MIM: 300157
HGNC: 3571
Ensembl: ENSG00000068366

Variants:

dbSNP: 2182
ClinVar: 2182
TCGA: ENSG00000068366
COSMIC: ACSL4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000068366ENST00000340800O60488
ENSG00000068366ENST00000348502O60488
ENSG00000068366ENST00000469796O60488
ENSG00000068366ENST00000469857A0A0C4DGB7
ENSG00000068366ENST00000502391D6RD96
ENSG00000068366ENST00000505855D6RF95
ENSG00000068366ENST00000508092D6RDA8
ENSG00000068366ENST00000514500H0Y9A0

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Fatty acid biosynthesisKEGGko00061
Fatty acid degradationKEGGko00071
PPAR signaling pathwayKEGGko03320
Adipocytokine signaling pathwayKEGGko04920
Fatty acid biosynthesisKEGGhsa00061
Fatty acid degradationKEGGhsa00071
PPAR signaling pathwayKEGGhsa03320
Adipocytokine signaling pathwayKEGGhsa04920
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
Metabolic pathwaysKEGGhsa01100
beta-Oxidation, acyl-CoA synthesisKEGGhsa_M00086
beta-Oxidation, acyl-CoA synthesisKEGGM00086
Fatty acid metabolismKEGGhsa01212
Fatty acid metabolismKEGGko01212
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Fatty Acyl-CoA BiosynthesisREACTOMER-HSA-75105
Synthesis of very long-chain fatty acyl-CoAsREACTOMER-HSA-75876
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203517142011Poor replication of candidate genes for major depressive disorder using genome-wide association data.92
275657262016Identification of ACSL4 as a biomarker and contributor of ferroptosis.52
117314232001Fatty acid CoA ligase 4 is up-regulated in colon adenocarcinoma.40
212425902011Long-chain acyl-CoA synthetase 4 modulates prostaglandin E₂ release from human arterial smooth muscle cells.36
210856062010Functional interaction between acyl-CoA synthetase 4, lipooxygenases and cyclooxygenase-2 in the aggressive phenotype of breast cancer cells.31
118894652002FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation.29
241559182013Long chain fatty Acyl-CoA synthetase 4 is a biomarker for and mediator of hormone resistance in human breast cancer.26
128248872003Fatty acid-CoA ligase 4 is overexpressed in human hepatocellular carcinoma.24
242013762014Differentially localized acyl-CoA synthetase 4 isoenzymes mediate the metabolic channeling of fatty acids towards phosphatidylinositol.24
228082642012The functional interaction between Acyl-CoA synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth: a novel therapeutic target.19

Citation

Dessen P

ACSL4 (acyl-CoA synthetase long chain family member 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45548/acsl4