Identity
HGNC
LOCATION
20q11.22
LOCUSID
ALIAS
ACAS2,ACECS,ACS,ACSA,AceCS1,dJ1161H23.1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 55902
MIM: 605832
HGNC: 15814
Ensembl: ENSG00000131069
Variants:
dbSNP: 55902
ClinVar: 55902
TCGA: ENSG00000131069
COSMIC: ACSS2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443309 | Alcoholism | Disease | ClinicalAnnotation | associated | PD | 28550509 | |
| PA443622 | Carcinoma, Non-Small-Cell Lung | Disease | ClinicalAnnotation | associated | PD | 21636554 | |
| PA448073 | ethanol | Chemical | ClinicalAnnotation | associated | PD | 28550509 | |
| PA448803 | carboplatin | Chemical | ClinicalAnnotation | associated | PD | 21636554 | |
| PA449014 | cisplatin | Chemical | ClinicalAnnotation | associated | PD | 21636554 | |
| PA449383 | docetaxel | Chemical | ClinicalAnnotation | associated | PD | 21636554 | |
| PA449748 | gemcitabine | Chemical | ClinicalAnnotation | associated | PD | 21636554 | |
| PA450761 | paclitaxel | Chemical | ClinicalAnnotation | associated | PD | 21636554 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36707625 | 2023 | ACSS2-mediated NF-κB activation promotes alkaliptosis in human pancreatic cancer cells. | 7 |
| 38051585 | 2023 | ACSS2 gene variants determine kidney disease risk by controlling de novo lipogenesis in kidney tubules. | 3 |
| 36707625 | 2023 | ACSS2-mediated NF-κB activation promotes alkaliptosis in human pancreatic cancer cells. | 7 |
| 38051585 | 2023 | ACSS2 gene variants determine kidney disease risk by controlling de novo lipogenesis in kidney tubules. | 3 |
| 35190642 | 2022 | O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation. | 20 |
| 35777482 | 2022 | Acetyl-Coenzyme A Synthetase 2 Potentiates Macropinocytosis and Muscle Wasting Through Metabolic Reprogramming in Pancreatic Cancer. | 7 |
| 35190642 | 2022 | O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation. | 20 |
| 35777482 | 2022 | Acetyl-Coenzyme A Synthetase 2 Potentiates Macropinocytosis and Muscle Wasting Through Metabolic Reprogramming in Pancreatic Cancer. | 7 |
| 34343565 | 2021 | Mammalian acetate-dependent acetyl CoA synthetase 2 contains multiple protein destabilization and masking elements. | 2 |
| 34343565 | 2021 | Mammalian acetate-dependent acetyl CoA synthetase 2 contains multiple protein destabilization and masking elements. | 2 |
| 31076106 | 2019 | Alternative transcription start site selection in ACSS2 controls its nuclear localization and promotes ribosome biosynthesis in hepatocellular carcinoma. | 6 |
| 31730405 | 2019 | miR-30a-GNG2 and miR-15b-ACSS2 Interaction Pairs May Be Potentially Crucial for Development of Abdominal Aortic Aneurysm by Influencing Inflammation. | 7 |
| 31814569 | 2019 | [Knockdown of ACSS2 inhibits invasion and migration of cervical cancer cells induced by nutrient stress and its mechanism]. | 3 |
| 31076106 | 2019 | Alternative transcription start site selection in ACSS2 controls its nuclear localization and promotes ribosome biosynthesis in hepatocellular carcinoma. | 6 |
| 31730405 | 2019 | miR-30a-GNG2 and miR-15b-ACSS2 Interaction Pairs May Be Potentially Crucial for Development of Abdominal Aortic Aneurysm by Influencing Inflammation. | 7 |
Citation
Dessen P
ACSS2 (acyl-CoA synthetase short chain family member 2)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/46903/acss2
