ACVR1B (activin A receptor type 1B)

2003-02-01  

Identity

HGNC
LOCATION
12q13.13
LOCUSID
ALIAS
ACTRIB,ACVRLK4,ALK4,SKR2
FUSION GENES

Other Information

Locus ID:

NCBI: 91
MIM: 601300
HGNC: 172
Ensembl: ENSG00000135503

Variants:

dbSNP: 91
ClinVar: 91
TCGA: ENSG00000135503
COSMIC: ACVR1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135503ENST00000257963P36896
ENSG00000135503ENST00000415850P36896
ENSG00000135503ENST00000426655P36896
ENSG00000135503ENST00000536420F5H5Q2
ENSG00000135503ENST00000541224P36896
ENSG00000135503ENST00000542485P36896

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
TGF-beta signaling pathwayKEGGko04350
Cytokine-cytokine receptor interactionKEGGhsa04060
TGF-beta signaling pathwayKEGGhsa04350
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Activin signalingKEGGhsa_M00681
Activin signalingKEGGM00681
Signal TransductionREACTOMER-HSA-162582
Signaling by ActivinREACTOMER-HSA-1502540
Developmental BiologyREACTOMER-HSA-1266738
Signaling by NODALREACTOMER-HSA-1181150
Regulation of signaling by NODALREACTOMER-HSA-1433617

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
179060792008MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4.97
232114912012MicroRNA miR-98 inhibits tumor angiogenesis and invasion by targeting activin receptor-like kinase-4 and matrix metalloproteinase-11.64
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
154593922004Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors.42
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
203472652010MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia.34
261493892015PU.1-Regulated Long Noncoding RNA lnc-MC Controls Human Monocyte/Macrophage Differentiation through Interaction with MicroRNA 199a-5p.33
274919542016The Expression of Human Cytomegalovirus MicroRNA MiR-UL148D during Latent Infection in Primary Myeloid Cells Inhibits Activin A-triggered Secretion of IL-6.25
167207242006FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor.24
151236862004An activin mutant with disrupted ALK4 binding blocks signaling via type II receptors.22

Citation

Dessen P

ACVR1B (activin A receptor type 1B)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/565/acvr1b