ACVR2B (activin A receptor type 2B)

2003-12-01  

Identity

HGNC
LOCATION
3p22.2
LOCUSID
ALIAS
ACTRIIB,ActR-IIB,HTX4
FUSION GENES

Other Information

Locus ID:

NCBI: 93
MIM: 602730
HGNC: 174
Ensembl: ENSG00000114739

Variants:

dbSNP: 93
ClinVar: 93
TCGA: ENSG00000114739
COSMIC: ACVR2B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114739ENST00000352511Q13705

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
TGF-beta signaling pathwayKEGGko04350
Cytokine-cytokine receptor interactionKEGGhsa04060
TGF-beta signaling pathwayKEGGhsa04350
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
BMP signalingKEGGhsa_M00679
Activin signalingKEGGhsa_M00681
BMP signalingKEGGM00679
Activin signalingKEGGM00681
Signal TransductionREACTOMER-HSA-162582
Signaling by BMPREACTOMER-HSA-201451
Signaling by ActivinREACTOMER-HSA-1502540
Developmental BiologyREACTOMER-HSA-1266738
Signaling by NODALREACTOMER-HSA-1181150
Regulation of signaling by NODALREACTOMER-HSA-1433617
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
224317212012miR-192, miR-194, miR-215, miR-200c and miR-141 are downregulated and their common target ACVR2B is strongly expressed in renal childhood neoplasms.48
204668012010Administration of a soluble activin type IIB receptor promotes skeletal muscle growth independent of fiber type.40
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
260479462015Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B.35
147388812004Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation.33
151236862004An activin mutant with disrupted ALK4 binding blocks signaling via type II receptors.22
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
252038452015microRNA-21 mediates stretch-induced osteogenic differentiation in human periodontal ligament stem cells.19
178933642007Crystal structure of activin receptor type IIB kinase domain from human at 2.0 Angstrom resolution.12
173473812007Activin-type II receptor B (ACVR2B) and follistatin haplotype associations with muscle mass and strength in humans.11

Citation

Dessen P

ACVR2B (activin A receptor type 2B)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/568/acvr2b