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ADA (adenosine deaminase)

Identity

Other names-
HGNC (Hugo) ADA
Location 20q13.12
Location_base_pair Starts at 42681577 and ends at 42713790 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ADA   186
Entrez_Gene (NCBI)ADA  100  adenosine deaminase
Cards
GeneCards (Weizmann)ADA
Ensembl (Hinxton)ENSG00000196839 [Gene_View]  ADA [Vega]
AceView (NCBI)ADA
Genatlas (Paris)ADA
euGene (Indiana)100
SOURCE (Stanford)NM_000022
Gene Expression (Array Express) ENSG00000196839
Genomic and cartography
GoldenPath (UCSC)ADA  -  20q13.12   chr20:42681577-42713790 -  20q13.12   [Description]    (hg18-March_2006)
EnsemblADA - 20q13.12 [CytoView]
Mapping of homologs : NCBIADA [Mapview]
OMIM102700   608958   
Gene and transcription
Gene : Genbank (Entrez)AK123988 AK223397 AL832305 BC007678 BC040226
Reference sequence (RefSeq transcript) :SRSNM_000022
Reference transcript : EntrezNM_000022
RefSeq genomic : SRSAC_000063 AC_000152 NC_000020 NG_007385 NT_011362 NW_001838666 NW_927339
RefSeq genomic : EntrezAC_000063 AC_000152 NC_000020 NG_007385 NT_011362 NW_001838666 NW_927339
Consensus coding sequences : CCDS NCBIADA
Cluster EST : UnigeneHs.654536 [ SRS ] Hs.654536 [ NCBI ]
Alternative Splicing : Fast-db (Paris)11872
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtP00813 (SRS) P00813 (Expasy) P00813 (Uniprot)
With graphics : InterProP00813
Splice isoforms : VarSplice FASTAP00813(VarSplice FASTA)
Domaine pattern : Prosite (SRS)A_DEAMINASE (PS00485)   
Domain pattern : Prosite (Expaxy)A_DEAMINASE (PS00485)   
Domains : Interpro (SRS)A/AMP_deam_AS    A/AMP_deaminase    A_deaminase   
Domains : Interpro (EBI)A/AMP_deam_AS    A/AMP_deaminase    A_deaminase   
Related proteins : CluSTrP00813
Domain families : Pfam SRSA_deaminase (PF00962)   
Domain families : Pfam SangerA_deaminase (PF00962)   
Domain families : Pfam NCBIpfam00962   
Blocks (Seattle)P00813
Crystal structure of protein : PDB SRS1M7M    3IAR   
Crystal structure of protein : PDBSum1M7M    3IAR   
Crystal structure of protein : IMB1M7M    3IAR   
Crystal structure of protein : PDB RSDB1M7M    3IAR   
HPRD00038
Protein Interaction databases
DIP (DOE-UCLA)P00813
IntAct (EBI)P00813
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBIADA
SNP : GeneSNP UtahADA
SNP : HGBaseADA
Genetic variants : HAPMAPADA
Somatic Mutations in Cancer : COSMICADA 
Mutations and Diseases : HGMDADA
Hereditary diseases : OMIM102700    608958   
Hereditary diseases : GENETests102700    608958   
Diseases : Genetic AssociationADA
General knowledge
Homologs : HomoloGeneADA
Homology/Alignments : Family Browser UCSCADA
Phylogenetic Trees/Animal Genes : TreeFamADA
Catalytic activity : Enzyme3.5.4.4 [ Enzyme-Expasy ]   3.5.4.4 [ Enzyme-SRS ]   3.5.4.4 [ IntEnz-EBI ]   3.5.4.4 [ BRENDA ]   3.5.4.4 [ KEGG ]   
Chemical/Protein Interactions : CTD100
Keywords Ontology : AmiGOresponse to hypoxia  in utero embryonic development  trophectodermal cell differentiation  purine nucleoside binding  liver development  placenta development  germinal center B cell differentiation  positive regulation of germinal center formation  negative regulation of leukocyte migration  negative regulation of mature B cell apoptosis  adenosine deaminase activity  adenosine deaminase activity  protein binding  extracellular space  cytoplasm  lysosome  cytosol  adenosine catabolic process  deoxyadenosine catabolic process  aging  zinc ion binding  nucleotide metabolic process  purine ribonucleoside monophosphate biosynthetic process  external side of plasma membrane  positive regulation of heart rate  membrane  hydrolase activity  positive regulation of B cell proliferation  purine nucleotide salvage  dendrite cytoplasm  positive regulation of T cell differentiation in the thymus  regulation of cell-cell adhesion mediated by integrin  response to hydrogen peroxide  cell soma  negative regulation of apoptosis  regulation of circadian sleep/wake cycle, sleep  positive regulation of smooth muscle contraction  dATP catabolic process  hypoxanthine biosynthetic process  inosine biosynthetic process  xanthine biosynthetic process  positive regulation of alpha-beta T cell differentiation  lung alveolus development  Peyer's patch development  embryonic gut development  negative regulation of inflammatory response  positive regulation of calcium-mediated signaling  positive regulation of T cell receptor signaling pathway  negative regulation of adenosine receptor signaling pathway  negative regulation of penile erection  negative regulation of thymocyte apoptosis  negative regulation of mucus secretion  
Keywords Ontology : EGO-EBIresponse to hypoxia  in utero embryonic development  trophectodermal cell differentiation  purine nucleoside binding  liver development  placenta development  germinal center B cell differentiation  positive regulation of germinal center formation  negative regulation of leukocyte migration  negative regulation of mature B cell apoptosis  adenosine deaminase activity  adenosine deaminase activity  protein binding  extracellular space  cytoplasm  lysosome  cytosol  adenosine catabolic process  deoxyadenosine catabolic process  aging  zinc ion binding  nucleotide metabolic process  purine ribonucleoside monophosphate biosynthetic process  external side of plasma membrane  positive regulation of heart rate  membrane  hydrolase activity  positive regulation of B cell proliferation  purine nucleotide salvage  dendrite cytoplasm  positive regulation of T cell differentiation in the thymus  regulation of cell-cell adhesion mediated by integrin  response to hydrogen peroxide  cell soma  negative regulation of apoptosis  regulation of circadian sleep/wake cycle, sleep  positive regulation of smooth muscle contraction  dATP catabolic process  hypoxanthine biosynthetic process  inosine biosynthetic process  xanthine biosynthetic process  positive regulation of alpha-beta T cell differentiation  lung alveolus development  Peyer's patch development  embryonic gut development  negative regulation of inflammatory response  positive regulation of calcium-mediated signaling  positive regulation of T cell receptor signaling pathway  negative regulation of adenosine receptor signaling pathway  negative regulation of penile erection  negative regulation of thymocyte apoptosis  negative regulation of mucus secretion  
Pathways : BIOCARTA
Pathways : KEGGPurine metabolism
Other databases
Probes
Probes : ImagenesADA Related clones (RZPD - Berlin)
Literature
PubMed115 Pubmed reference(s) in Entrez
PubGeneADA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 27 10:30:17 CET 2010
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