ADAM22 (ADAM metallopeptidase domain 22)

2007-04-01  

Identity

HGNC
ADAM22
LOCATION
7q21.12
LOCUSID
53616
ALIAS
ADAM
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 53616
MIM: 603709
HGNC: 201
Ensembl: ENSG00000008277

Variants:

dbSNP: 53616
ClinVar: 53616
TCGA: ENSG00000008277
COSMIC: ADAM22

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000008277ENST00000265727Q9P0K1
ENSG00000008277ENST00000398201Q9P0K1
ENSG00000008277ENST00000398203F8WAD8
ENSG00000008277ENST00000398204Q9P0K1
ENSG00000008277ENST00000398209Q9P0K1
ENSG00000008277ENST00000412441E9PF78
ENSG00000008277ENST00000413139H7C3I4
ENSG00000008277ENST00000426930H7C0Q9
ENSG00000008277ENST00000439864E7EPF1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
LGI-ADAM interactionsREACTOMER-HSA-5682910

References

Pubmed IDYearTitleCitations
242277252013Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors.84
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
202200212010Adam22 is a major neuronal receptor for Lgi4-mediated Schwann cell signaling.24
190545712009Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence.18
220725662012Global characterization of the SRC-1 transcriptome identifies ADAM22 as an ER-independent mediator of endocrine-resistant breast cancer.17
163853422006ADAM22, expressed in normal brain but not in high-grade gliomas, inhibits cellular proliferation via the disintegrin domain.13
184407802008Autosomal dominant lateral temporal epilepsy: absence of mutations in ADAM22 and Kv1 channel genes encoding LGI1-associated proteins.10
158829682005ADAM22 plays an important role in cell adhesion and spreading with the assistance of 14-3-3.7
176814542007Absence of mutations in the LGI1 receptor ADAM22 gene in autosomal dominant lateral temporal epilepsy.7
125898112003The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading.6

Citation

Dessen P

ADAM22 (ADAM metallopeptidase domain 22)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47115/adam22