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ADAM22 (ADAM metallopeptidase domain 22)

Identity

Alias_namesa disintegrin and metalloproteinase domain 22
Alias_symbol (synonym)MDC2
Other aliasADAM 22
EIEE61
HGNC (Hugo) ADAM22
LocusID (NCBI) 53616
Atlas_Id 47115
Location 7q21.12  [Link to chromosome band 7q21]
Location_base_pair Starts at 87934143 and ends at 88202889 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BMPER (7p14.3) / ADAM22 (7q21.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ADAM22   201
Cards
Entrez_Gene (NCBI)ADAM22  53616  ADAM metallopeptidase domain 22
AliasesADAM; EIEE61; MDC2
GeneCards (Weizmann)ADAM22
Ensembl hg19 (Hinxton)ENSG00000008277 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000008277 [Gene_View]  ENSG00000008277 [Sequence]  chr7:87934143-88202889 [Contig_View]  ADAM22 [Vega]
ICGC DataPortalENSG00000008277
TCGA cBioPortalADAM22
AceView (NCBI)ADAM22
Genatlas (Paris)ADAM22
WikiGenes53616
SOURCE (Princeton)ADAM22
Genetics Home Reference (NIH)ADAM22
Genomic and cartography
GoldenPath hg38 (UCSC)ADAM22  -     chr7:87934143-88202889 +  7q21.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADAM22  -     7q21.12   [Description]    (hg19-Feb_2009)
GoldenPathADAM22 - 7q21.12 [CytoView hg19]  ADAM22 - 7q21.12 [CytoView hg38]
ImmunoBaseENSG00000008277
Mapping of homologs : NCBIADAM22 [Mapview hg19]  ADAM22 [Mapview hg38]
OMIM603709   617933   
Gene and transcription
Genbank (Entrez)AB009671 AB009671 AF073291 AF155381 AF155382
RefSeq transcript (Entrez)NM_001324417 NM_001324418 NM_001324419 NM_001324420 NM_001324421 NM_004194 NM_016351 NM_021721 NM_021722 NM_021723
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADAM22
Cluster EST : UnigeneHs.256398 [ NCBI ]
CGAP (NCI)Hs.256398
Alternative Splicing GalleryENSG00000008277
Gene ExpressionADAM22 [ NCBI-GEO ]   ADAM22 [ EBI - ARRAY_EXPRESS ]   ADAM22 [ SEEK ]   ADAM22 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAM22 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)53616
GTEX Portal (Tissue expression)ADAM22
Human Protein AtlasENSG00000008277-ADAM22 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P0K1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P0K1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P0K1
Splice isoforms : SwissVarQ9P0K1
PhosPhoSitePlusQ9P0K1
Domaine pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    DISINTEGRIN_1 (PS00427)    DISINTEGRIN_2 (PS50214)    EGF_1 (PS00022)   
Domains : Interpro (EBI)ADAM_Cys-rich    Disintegrin_CS    Disintegrin_dom    Disintegrin_dom_sf    EGF-like_CS    EGF_extracell    MetalloPept_cat_dom_sf    Peptidase_M12B    Peptidase_M12B_N    Reprolysin_adamalysin   
Domain families : Pfam (Sanger)ADAM_CR (PF08516)    Disintegrin (PF00200)    EGF_2 (PF07974)    Pep_M12B_propep (PF01562)    Reprolysin (PF01421)   
Domain families : Pfam (NCBI)pfam08516    pfam00200    pfam07974    pfam01562    pfam01421   
Domain families : Smart (EMBL)ACR (SM00608)  DISIN (SM00050)  
Conserved Domain (NCBI)ADAM22
DMDM Disease mutations53616
Blocks (Seattle)ADAM22
PDB (RSDB)3G5C   
PDB Europe3G5C   
PDB (PDBSum)3G5C   
PDB (IMB)3G5C   
Structural Biology KnowledgeBase3G5C   
SCOP (Structural Classification of Proteins)3G5C   
CATH (Classification of proteins structures)3G5C   
SuperfamilyQ9P0K1
Human Protein Atlas [tissue]ENSG00000008277-ADAM22 [tissue]
Peptide AtlasQ9P0K1
HPRD04751
IPIIPI00220631   IPI00220632   IPI00220634   IPI00220635   IPI00941986   IPI01015139   IPI00789795   IPI00925617   IPI00924922   IPI00927866   
Protein Interaction databases
DIP (DOE-UCLA)Q9P0K1
IntAct (EBI)Q9P0K1
FunCoupENSG00000008277
BioGRIDADAM22
STRING (EMBL)ADAM22
ZODIACADAM22
Ontologies - Pathways
QuickGOQ9P0K1
Ontology : AmiGOmetalloendopeptidase activity  integrin binding  protein binding  plasma membrane  plasma membrane  proteolysis  cell adhesion  negative regulation of cell adhesion  central nervous system development  adult locomotory behavior  integral component of membrane  integral component of membrane  myelination in peripheral nervous system  axon  glutamatergic synapse  integral component of postsynaptic density membrane  neurotransmitter receptor localization to postsynaptic specialization membrane  
Ontology : EGO-EBImetalloendopeptidase activity  integrin binding  protein binding  plasma membrane  plasma membrane  proteolysis  cell adhesion  negative regulation of cell adhesion  central nervous system development  adult locomotory behavior  integral component of membrane  integral component of membrane  myelination in peripheral nervous system  axon  glutamatergic synapse  integral component of postsynaptic density membrane  neurotransmitter receptor localization to postsynaptic specialization membrane  
NDEx NetworkADAM22
Atlas of Cancer Signalling NetworkADAM22
Wikipedia pathwaysADAM22
Orthology - Evolution
OrthoDB53616
GeneTree (enSembl)ENSG00000008277
Phylogenetic Trees/Animal Genes : TreeFamADAM22
HOGENOMQ9P0K1
Homologs : HomoloGeneADAM22
Homology/Alignments : Family Browser (UCSC)ADAM22
Gene fusions - Rearrangements
Fusion : QuiverADAM22
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAM22 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAM22
dbVarADAM22
ClinVarADAM22
1000_GenomesADAM22 
Exome Variant ServerADAM22
ExAC (Exome Aggregation Consortium)ENSG00000008277
GNOMAD BrowserENSG00000008277
Varsome BrowserADAM22
Genetic variants : HAPMAP53616
Genomic Variants (DGV)ADAM22 [DGVbeta]
DECIPHERADAM22 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADAM22 
Mutations
ICGC Data PortalADAM22 
TCGA Data PortalADAM22 
Broad Tumor PortalADAM22
OASIS PortalADAM22 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAM22  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DADAM22
Mutations and Diseases : HGMDADAM22
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADAM22
DgiDB (Drug Gene Interaction Database)ADAM22
DoCM (Curated mutations)ADAM22 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADAM22 (select a term)
intoGenADAM22
Cancer3DADAM22(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603709    617933   
Orphanet
DisGeNETADAM22
MedgenADAM22
Genetic Testing Registry ADAM22
NextProtQ9P0K1 [Medical]
TSGene53616
GENETestsADAM22
Target ValidationADAM22
Huge Navigator ADAM22 [HugePedia]
snp3D : Map Gene to Disease53616
BioCentury BCIQADAM22
ClinGenADAM22
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD53616
Chemical/Pharm GKB GenePA24518
Clinical trialADAM22
Miscellaneous
canSAR (ICR)ADAM22 (select the gene name)
DataMed IndexADAM22
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADAM22
EVEXADAM22
GoPubMedADAM22
iHOPADAM22
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:31:07 CET 2019
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