ADAMDEC1 (ADAM like decysin 1)

2007-04-01  

Identity

HGNC
LOCATION
8p21.2
LOCUSID
ALIAS
M12.219
FUSION GENES

Other Information

Locus ID:

NCBI: 27299
MIM: 606393
HGNC: 16299
Ensembl: ENSG00000134028

Variants:

dbSNP: 27299
ClinVar: 27299
TCGA: ENSG00000134028
COSMIC: ADAMDEC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134028ENST00000256412O15204
ENSG00000134028ENST00000520193E5RK05
ENSG00000134028ENST00000522298O15204

Expression (GTEx)

0
50
100
150
200

References

Pubmed IDYearTitleCitations
192181962009Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis.44
120376022002The ADAMDEC1 (decysin) gene structure: evolution by duplication in a metalloprotease gene cluster on chromosome 8p12.20
237542852013ADAMDEC1 is a metzincin metalloprotease with dampened proteolytic activity.9
284554452017The soluble protease ADAMDEC1 released from activated platelets hydrolyzes platelet membrane pro-epidermal growth factor (EGF) to active high-molecular-weight EGF.7
255646182015Evidence for restricted reactivity of ADAMDEC1 with protein substrates and endogenous inhibitors.4
299419812018ADAM-like Decysin-1 (ADAMDEC1) is a positive regulator of Epithelial Defense Against Cancer (EDAC) that promotes apical extrusion of RasV12-transformed cells.3
303523652018Enhancer RNA and NFκB-dependent P300 regulation of ADAMDEC1.3
184494202008Association of ADAMDEC1 haplotype with high factor VIII levels in venous thromboembolism.1
184494202008Association of ADAMDEC1 haplotype with high factor VIII levels in venous thromboembolism.1

Citation

Dessen P

ADAMDEC1 (ADAM like decysin 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47508/adamdec1