ADAMTS5 (ADAM metallopeptidase with thrombospondin type 1 motif 5)

2007-02-01  

Identity

HGNC
LOCATION
21q21.3
LOCUSID
ALIAS
ADAM-TS
FUSION GENES

Other Information

Locus ID:

NCBI: 11096
MIM: 605007
HGNC: 221
Ensembl: ENSG00000154736

Variants:

dbSNP: 11096
ClinVar: 11096
TCGA: ENSG00000154736
COSMIC: ADAMTS5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154736ENST00000284987Q9UNA0
ENSG00000154736ENST00000652031A0A494C1E4

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-glycosylation of TSR domain-containing proteinsREACTOMER-HSA-5173214
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Diseases associated with O-glycosylation of proteinsREACTOMER-HSA-3906995
Defective B3GALTL causes Peters-plus syndrome (PpS)REACTOMER-HSA-5083635

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
385361972024ADAMTS5 Promotes Permeability of the Blood-Brain Barrier during Treponema pallidum Subspecies pallidum Invading the Central Nervous System.0
389403272024SP1‑mediated ADAMTS5 transcription promotes IL‑1β‑induced chondrocyte injury via Wnt/β‑catenin pathway in osteoarthritis.0
385361972024ADAMTS5 Promotes Permeability of the Blood-Brain Barrier during Treponema pallidum Subspecies pallidum Invading the Central Nervous System.0
389403272024SP1‑mediated ADAMTS5 transcription promotes IL‑1β‑induced chondrocyte injury via Wnt/β‑catenin pathway in osteoarthritis.0
351686392022Elevation of MMP1 and ADAMTS5 mRNA expression in glenohumeral synovia of patients with hypercholesterolemia.0
352366442022MicroRNA-148a targets ADAMTS5 to inhibit proliferation of endometriosis cells.2
353170992022Differential DNA methylation analysis of SUMF2, ADAMTS5, and PXDN provides novel insights into colorectal cancer prognosis prediction in Taiwan.3
351686392022Elevation of MMP1 and ADAMTS5 mRNA expression in glenohumeral synovia of patients with hypercholesterolemia.0
352366442022MicroRNA-148a targets ADAMTS5 to inhibit proliferation of endometriosis cells.2
353170992022Differential DNA methylation analysis of SUMF2, ADAMTS5, and PXDN provides novel insights into colorectal cancer prognosis prediction in Taiwan.3
331289182021Long non-coding RNA XIST regulates chondrogenic differentiation of synovium-derived mesenchymal stem cells from temporomandibular joint via miR-27b-3p/ADAMTS-5 axis.8
334419042021Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide.12
334444942021ADAMTS proteoglycanases downregulation with impaired oocyte quality in PCOS.1
335224332021In Silico Identification of Contradictory Role of ADAMTS5 in Hepatocellular Carcinoma.4
339340892021Internal modulation of proteolysis in vascular extracellular matrix remodeling: role of ADAM metallopeptidase with thrombospondin type 1 motif 5 in the development of intracranial aneurysm rupture.2

Citation

Dessen P

ADAMTS5 (ADAM metallopeptidase with thrombospondin type 1 motif 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46151/adamts5