ADARB1 (adenosine deaminase RNA specific B1)

2012-12-01  

Identity

HGNC
LOCATION
21q22.3
LOCUSID
ALIAS
ADAR2,DRABA2,DRADA2,NEDHYMS,RED1
FUSION GENES

Other Information

Locus ID:

NCBI: 104
MIM: 601218
HGNC: 226
Ensembl: ENSG00000197381

Variants:

dbSNP: 104
ClinVar: 104
TCGA: ENSG00000197381
COSMIC: ADARB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197381ENST00000348831P78563
ENSG00000197381ENST00000360697P78563
ENSG00000197381ENST00000389863P78563
ENSG00000197381ENST00000437626P78563
ENSG00000197381ENST00000449478A0A0A0MSG8
ENSG00000197381ENST00000492414P78563
ENSG00000197381ENST00000496664P78563
ENSG00000197381ENST00000611195Q8TCX7
ENSG00000197381ENST00000629643P78563

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
mRNA EditingREACTOMER-HSA-75072
mRNA Editing: A to I ConversionREACTOMER-HSA-75064
Formation of editosomes by ADAR proteinsREACTOMER-HSA-77042
C6 deamination of adenosineREACTOMER-HSA-75102

References

Pubmed IDYearTitleCitations
161410672005Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing.173
197139322009Editing independent effects of ADARs on the miRNA/siRNA pathways.81
181785532008Down-regulation of RNA editing in pediatric astrocytomas: ADAR2 editing activity inhibits cell migration and proliferation.75
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
222269992012Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neurons.51
225252742013ADAR2-editing activity inhibits glioblastoma growth through the modulation of the CDC14B/Skp2/p21/p27 axis.44
270651962016Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity.43
255820552015Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma.41
200115872009RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans.37
153836782004Evidence for auto-inhibition by the N terminus of hADAR2 and activation by dsRNA binding.32

Citation

Dessen P

ADARB1 (adenosine deaminase RNA specific B1)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53086/adarb1