Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 112
MIM: 600294
HGNC: 237
Ensembl: ENSG00000174233
Variants:
dbSNP: 112
ClinVar: 112
TCGA: ENSG00000174233
COSMIC: ADCY6
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000174233 | ENST00000307885 | O43306 |
| ENSG00000174233 | ENST00000357869 | O43306 |
| ENSG00000174233 | ENST00000548820 | F8VZJ5 |
| ENSG00000174233 | ENST00000550422 | O43306 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA172 | GNAI1 | Gene | Pathway | associated | |||
| PA173 | GNAI3 | Gene | Pathway | associated | |||
| PA175 | GNAS | Gene | Pathway | associated | |||
| PA24347 | GNAI2 | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 31846058 | 2020 | Expanding the clinical and molecular spectrum of lethal congenital contracture syndrome 8 associated with biallelic variants of ADCY6. | 3 |
| 31886586 | 2020 | Gene expression and DNA methylation analyses suggest that immune process-related ADCY6 is a prognostic factor of luminal-like breast cancer. | 11 |
| 31846058 | 2020 | Expanding the clinical and molecular spectrum of lethal congenital contracture syndrome 8 associated with biallelic variants of ADCY6. | 3 |
| 31886586 | 2020 | Gene expression and DNA methylation analyses suggest that immune process-related ADCY6 is a prognostic factor of luminal-like breast cancer. | 11 |
| 31068382 | 2019 | Effect of Adenylyl Cyclase Type 6 on Localized Production of cAMP by β-2 Adrenoceptors in Human Airway Smooth-Muscle Cells. | 7 |
| 31383768 | 2019 | Activity of Adenylyl Cyclase Type 6 Is Suppressed by Direct Binding of the Cytoskeletal Protein 4.1G. | 4 |
| 31068382 | 2019 | Effect of Adenylyl Cyclase Type 6 on Localized Production of cAMP by β-2 Adrenoceptors in Human Airway Smooth-Muscle Cells. | 7 |
| 31383768 | 2019 | Activity of Adenylyl Cyclase Type 6 Is Suppressed by Direct Binding of the Cytoskeletal Protein 4.1G. | 4 |
| 29262264 | 2018 | PDE8 Is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by β(2)-Adrenergic Receptors and Adenylyl Cyclase 6. | 26 |
| 29327289 | 2018 | Study of adenylyl cyclase-GαS interactions and identification of novel AC ligands. | 7 |
| 29443612 | 2018 | Elevated Vasodilatory Cyclases and Shorter Telomere Length Contribute to High-Altitude Pulmonary Edema. | 0 |
| 29262264 | 2018 | PDE8 Is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by β(2)-Adrenergic Receptors and Adenylyl Cyclase 6. | 26 |
| 29327289 | 2018 | Study of adenylyl cyclase-GαS interactions and identification of novel AC ligands. | 7 |
| 29443612 | 2018 | Elevated Vasodilatory Cyclases and Shorter Telomere Length Contribute to High-Altitude Pulmonary Edema. | 0 |
| 27067484 | 2016 | Association of adenylyl cyclase 6 rs3730070 polymorphism and hemolytic level in patients with sickle cell anemia. | 1 |
Citation
Dessen P
ADCY6 (adenylate cyclase 6)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/579/adcy6
