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ADGRF4 (adhesion G protein-coupled receptor F4)

Identity

Alias_namesGPR115
G protein-coupled receptor 115
Alias_symbol (synonym)FLJ38076
PGR18
Other alias
HGNC (Hugo) ADGRF4
LocusID (NCBI) 221393
Atlas_Id 77567
Location 6p12.3  [Link to chromosome band 6p12]
Location_base_pair Starts at 47698545 and ends at 47722021 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADGRF4 (6p12.3) / CALR (19p13.2)ADGRF4 (6p12.3) / LAMB3 (1q32.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;19)(p12;p13) ADGRF4/CALR

External links

Nomenclature
HGNC (Hugo)ADGRF4   19011
Cards
Entrez_Gene (NCBI)ADGRF4  221393  adhesion G protein-coupled receptor F4
AliasesGPR115; PGR18
GeneCards (Weizmann)ADGRF4
Ensembl hg19 (Hinxton)ENSG00000153294 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000153294 [Gene_View]  ENSG00000153294 [Sequence]  chr6:47698545-47722021 [Contig_View]  ADGRF4 [Vega]
ICGC DataPortalENSG00000153294
TCGA cBioPortalADGRF4
AceView (NCBI)ADGRF4
Genatlas (Paris)ADGRF4
WikiGenes221393
SOURCE (Princeton)ADGRF4
Genetics Home Reference (NIH)ADGRF4
Genomic and cartography
GoldenPath hg38 (UCSC)ADGRF4  -     chr6:47698545-47722021 +  6p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADGRF4  -     6p12.3   [Description]    (hg19-Feb_2009)
GoldenPathADGRF4 - 6p12.3 [CytoView hg19]  ADGRF4 - 6p12.3 [CytoView hg38]
ImmunoBaseENSG00000153294
Mapping of homologs : NCBIADGRF4 [Mapview hg19]  ADGRF4 [Mapview hg38]
OMIM614268   
Gene and transcription
Genbank (Entrez)AK095395 AK129826 AY255556 BP336304 BU683873
RefSeq transcript (Entrez)NM_001347855 NM_153838
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADGRF4
Alternative Splicing GalleryENSG00000153294
Gene ExpressionADGRF4 [ NCBI-GEO ]   ADGRF4 [ EBI - ARRAY_EXPRESS ]   ADGRF4 [ SEEK ]   ADGRF4 [ MEM ]
Gene Expression Viewer (FireBrowse)ADGRF4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)221393
GTEX Portal (Tissue expression)ADGRF4
Human Protein AtlasENSG00000153294-ADGRF4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IZF3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IZF3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IZF3
Splice isoforms : SwissVarQ8IZF3
PhosPhoSitePlusQ8IZF3
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F2_4 (PS50261)    GPS (PS50221)   
Domains : Interpro (EBI)GPCR_2-like    GPCR_2_Ig-hepta-like_rcpt    GPCR_2_secretin-like    GPS   
Domain families : Pfam (Sanger)7tm_2 (PF00002)    GPS (PF01825)   
Domain families : Pfam (NCBI)pfam00002    pfam01825   
Conserved Domain (NCBI)ADGRF4
DMDM Disease mutations221393
Blocks (Seattle)ADGRF4
SuperfamilyQ8IZF3
Human Protein Atlas [tissue]ENSG00000153294-ADGRF4 [tissue]
Peptide AtlasQ8IZF3
HPRD17057
IPIIPI00217512   IPI00217998   
Protein Interaction databases
DIP (DOE-UCLA)Q8IZF3
IntAct (EBI)Q8IZF3
FunCoupENSG00000153294
BioGRIDADGRF4
STRING (EMBL)ADGRF4
ZODIACADGRF4
Ontologies - Pathways
QuickGOQ8IZF3
Ontology : AmiGOG protein-coupled receptor activity  cell surface receptor signaling pathway  G protein-coupled receptor signaling pathway  integral component of membrane  
Ontology : EGO-EBIG protein-coupled receptor activity  cell surface receptor signaling pathway  G protein-coupled receptor signaling pathway  integral component of membrane  
NDEx NetworkADGRF4
Atlas of Cancer Signalling NetworkADGRF4
Wikipedia pathwaysADGRF4
Orthology - Evolution
OrthoDB221393
GeneTree (enSembl)ENSG00000153294
Phylogenetic Trees/Animal Genes : TreeFamADGRF4
HOGENOMQ8IZF3
Homologs : HomoloGeneADGRF4
Homology/Alignments : Family Browser (UCSC)ADGRF4
Gene fusions - Rearrangements
Fusion : QuiverADGRF4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADGRF4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADGRF4
dbVarADGRF4
ClinVarADGRF4
1000_GenomesADGRF4 
Exome Variant ServerADGRF4
ExAC (Exome Aggregation Consortium)ENSG00000153294
GNOMAD BrowserENSG00000153294
Varsome BrowserADGRF4
Genetic variants : HAPMAP221393
Genomic Variants (DGV)ADGRF4 [DGVbeta]
DECIPHERADGRF4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADGRF4 
Mutations
ICGC Data PortalADGRF4 
TCGA Data PortalADGRF4 
Broad Tumor PortalADGRF4
OASIS PortalADGRF4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADGRF4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DADGRF4
Mutations and Diseases : HGMDADGRF4
BioMutasearch ADGRF4
DgiDB (Drug Gene Interaction Database)ADGRF4
DoCM (Curated mutations)ADGRF4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADGRF4 (select a term)
intoGenADGRF4
Cancer3DADGRF4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614268   
Orphanet
DisGeNETADGRF4
MedgenADGRF4
Genetic Testing Registry ADGRF4
NextProtQ8IZF3 [Medical]
TSGene221393
GENETestsADGRF4
Target ValidationADGRF4
Huge Navigator ADGRF4 [HugePedia]
snp3D : Map Gene to Disease221393
BioCentury BCIQADGRF4
ClinGenADGRF4
Clinical trials, drugs, therapy
Protein Interactions : CTD221393
Pharm GKB GenePA134954617
Clinical trialADGRF4
Miscellaneous
canSAR (ICR)ADGRF4 (select the gene name)
HarmonizomeADGRF4
DataMed IndexADGRF4
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADGRF4
EVEXADGRF4
GoPubMedADGRF4
iHOPADGRF4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Jun 30 19:34:01 CEST 2020
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