ADGRF5 (adhesion G protein-coupled receptor F5)

2014-05-01  

Identity

HGNC
ADGRF5
LOCATION
6p12.3
LOCUSID
221395
ALIAS
GPR116,KPG_001
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 221395
HGNC: 19030
Ensembl: ENSG00000069122

Variants:

dbSNP: 221395
ClinVar: 221395
TCGA: ENSG00000069122
COSMIC: ADGRF5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000069122ENST00000265417Q8IZF2
ENSG00000069122ENST00000283296Q8IZF2

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Surfactant metabolismREACTOMER-HSA-5683826

References

Pubmed IDYearTitleCitations
185198262008Molecular genetics of successful smoking cessation: convergent genome-wide association study results.130
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
240083162013GPR116, an adhesion G-protein-coupled receptor, promotes breast cancer metastasis via the Gαq-p63RhoGEF-Rho GTPase pathway.37
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
183141332008SEA domain autoproteolysis accelerated by conformational strain: mechanistic aspects.7
183083342008SEA domain autoproteolysis accelerated by conformational strain: energetic aspects.6
286247862017High expression of GPR116 indicates poor survival outcome and promotes tumor progression in colorectal carcinoma.4

Citation

Dessen P

ADGRF5 (adhesion G protein-coupled receptor F5)

Atlas Genet Cytogenet Oncol Haematol. 2014-05-01

Online version: http://atlasgeneticsoncology.org/gene/53899/adgrf5