ADGRG2 (adhesion G protein-coupled receptor G2)

2003-05-01  

Identity

HGNC
LOCATION
Xp22.13
LOCUSID
ALIAS
CBAVDX,EDDM6,GPR64,HE6,TM7LN2

Other Information

Locus ID:

NCBI: 10149
MIM: 300572
HGNC: 4516
Ensembl: ENSG00000173698

Variants:

dbSNP: 10149
ClinVar: 10149
TCGA: ENSG00000173698
COSMIC: ADGRG2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173698ENST00000340581Q8IZP9
ENSG00000173698ENST00000354791Q8IZP9
ENSG00000173698ENST00000356606Q8IZP9
ENSG00000173698ENST00000357544Q8IZP9
ENSG00000173698ENST00000357991Q8IZP9
ENSG00000173698ENST00000360279Q8IZP9
ENSG00000173698ENST00000379869Q8IZP9
ENSG00000173698ENST00000379873Q8IZP9
ENSG00000173698ENST00000379876Q8IZP9
ENSG00000173698ENST00000379878Q8IZP9

Expression (GTEx)

0
1
2
3
4
5
6
7

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
263212312015The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration.18
274766562016Truncating Mutations in the Adhesion G Protein-Coupled Receptor G2 Gene ADGRG2 Cause an X-Linked Congenital Bilateral Absence of Vas Deferens.13
288059482017Pathogenic role of ADGRG2 in CBAVD patients replicated in Chinese population.8
277604552017Orphan Adhesion GPCR GPR64/ADGRG2 Is Overexpressed in Parathyroid Tumors and Attenuates Calcium-Sensing Receptor-Mediated Signaling.7
303899582018X-linked ADGRG2 mutation and obstructive azoospermia in a large Pakistani family.5
286945022017G-protein coupled receptor 64 is required for decidualization of endometrial stromal cells.1
314128162019G-protein coupled receptor 64 (GPR64) acts as a tumor suppressor in endometrial cancer.1
315022832019Spatial regulation of GPR64/ADGRG2 signaling by β-arrestins and GPCR kinases.1

Citation

Dessen P

ADGRG2 (adhesion G protein-coupled receptor G2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40744/adgrg2