Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 124
MIM: 103700
HGNC: 249
Ensembl: ENSG00000187758
Variants:
dbSNP: 124
ClinVar: 124
TCGA: ENSG00000187758
COSMIC: ADH1A
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000187758 | ENST00000209668 | P07327 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166155185 | rs1234612 | Variant | VipGene | associated | |||
| PA166156497 | rs975833 | Variant | VipGene | associated | |||
| PA166186245 | acetaldehyde | Chemical | ClinicalAnnotation | associated | PK | 31002879 | |
| PA443309 | Alcoholism | Disease | VipGene | associated | |||
| PA448004 | abacavir | Chemical | Pathway | associated | 24625462 | ||
| PA448073 | ethanol | Chemical | VipGene | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34742856 | 2022 | Contrary to consensus, oxidation of ethanol by human alcohol dehydrogenase (ADH) 1A is activated by ATP. | 0 |
| 34742856 | 2022 | Contrary to consensus, oxidation of ethanol by human alcohol dehydrogenase (ADH) 1A is activated by ATP. | 0 |
| 31002879 | 2019 | The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea. | 6 |
| 31002879 | 2019 | The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea. | 6 |
| 29248712 | 2018 | Genetic variant repressing ADH1A expression confers susceptibility to esophageal squamous-cell carcinoma. | 4 |
| 29739065 | 2018 | The Activity of Alcohol Dehydrogenase Isoenzymes and Aldehyde Dehydrogenase in the Sera of Patients with Autoimmune Hepatitis. | 2 |
| 29248712 | 2018 | Genetic variant repressing ADH1A expression confers susceptibility to esophageal squamous-cell carcinoma. | 4 |
| 29739065 | 2018 | The Activity of Alcohol Dehydrogenase Isoenzymes and Aldehyde Dehydrogenase in the Sera of Patients with Autoimmune Hepatitis. | 2 |
| 28870918 | 2017 | The Diagnostic Significance of Serum Alcohol Dehydrogenase Isoenzymes and Aldehyde Dehydrogenase Activity in Prostate Cancer Patients. | 3 |
| 28870918 | 2017 | The Diagnostic Significance of Serum Alcohol Dehydrogenase Isoenzymes and Aldehyde Dehydrogenase Activity in Prostate Cancer Patients. | 3 |
| 27086037 | 2016 | The diagnostic significance of serum alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase activity in renal cell cancer patients. | 2 |
| 27086037 | 2016 | The diagnostic significance of serum alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase activity in renal cell cancer patients. | 2 |
| 24762066 | 2014 | Changes in aldehyde dehydrogenase-1 expression during neoadjuvant chemotherapy predict outcome in locally advanced breast cancer. | 28 |
| 24762066 | 2014 | Changes in aldehyde dehydrogenase-1 expression during neoadjuvant chemotherapy predict outcome in locally advanced breast cancer. | 28 |
| 23468174 | 2013 | Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism. | 13 |
Citation
Dessen P
ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide)
Atlas Genet Cytogenet Oncol Haematol. 2012-12-01
Online version: http://atlasgeneticsoncology.org/gene/53093/adh1a
