Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 125
MIM: 103720
HGNC: 250
Ensembl: ENSG00000196616
Variants:
dbSNP: 125
ClinVar: 125
TCGA: ENSG00000196616
COSMIC: ADH1B
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000196616 | ENST00000305046 | P00325 |
| ENSG00000196616 | ENST00000506651 | D6RHZ6 |
| ENSG00000196616 | ENST00000625860 | D6RHZ6 |
| ENSG00000196616 | ENST00000639454 | V9HW50 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166156507 | rs1229984 | Variant | VipGene | associated | 16571603, 16792560, 15099407 | ||
| PA166156533 | rs2066702 | Variant | VipGene | associated | 16571603 | ||
| PA166186245 | acetaldehyde | Chemical | ClinicalAnnotation | associated | PK | 31002879 | |
| PA443309 | Alcoholism | Disease | ClinicalAnnotation, VipGene | associated | PD | 15902904, 16086315, 32451486 | |
| PA443450 | Asthma | Disease | VipGene | associated | 15099407 | ||
| PA443635 | Cardiovascular Diseases | Disease | VipGene | associated | 15099407 | ||
| PA444167 | Fetal Alcohol Syndrome | Disease | VipGene | associated | 15099407 | ||
| PA444318 | Gout | Disease | VipGene | associated | 15099407 | ||
| PA444802 | Liver Diseases, Alcoholic | Disease | VipGene | associated | 15099407 | ||
| PA445168 | Oropharyngeal Neoplasms | Disease | VipGene | associated | 15099407 | ||
| PA448004 | abacavir | Chemical | Pathway | associated | 24625462 | ||
| PA448073 | ethanol | Chemical | ClinicalAnnotation, VipGene | associated | PK | PD | 15902904, 16571603, 23240771, 32451486 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38331848 | 2024 | Interaction of genetic variation at ADH1B and MLXIPL with alcohol consumption for elevated serum urate level and gout among people of European ethnicity. | 1 |
| 38838011 | 2024 | ADH1B, the adipocyte-enriched alcohol dehydrogenase, plays an essential, cell-autonomous role in human adipogenesis. | 0 |
| 38331848 | 2024 | Interaction of genetic variation at ADH1B and MLXIPL with alcohol consumption for elevated serum urate level and gout among people of European ethnicity. | 1 |
| 38838011 | 2024 | ADH1B, the adipocyte-enriched alcohol dehydrogenase, plays an essential, cell-autonomous role in human adipogenesis. | 0 |
| 35670037 | 2023 | Impacts of ADH1B rs1229984 and ALDH2 rs671 polymorphisms on risks of alcohol-related disorder and cancer. | 9 |
| 36565468 | 2023 | Effects of the genetic variants of alcohol-metabolizing enzymes on lipid levels in Asian populations: a systematic review and meta-analysis. | 1 |
| 37291211 | 2023 | Alcohol consumption and risks of more than 200 diseases in Chinese men. | 18 |
| 37378938 | 2023 | Association of ADH1B rs1229984, ADH1C rs698, and ALDH2 rs671 with Alcohol abuse and Alcoholic Cirrhosis in People Living in Northeast Vietnam. | 1 |
| 37392542 | 2023 | Associations of alcohol intake with subclinical carotid atherosclerosis in 22,000 Chinese adults. | 1 |
| 37510297 | 2023 | ADH1B, ADH1B/C and CYP2E1 Gene Polymorphism and the Risk of Fetal Alcohol Spectrum Disorder. | 1 |
| 37795758 | 2023 | Relationship between esophageal squamous cell carcinoma risk and alcohol-related ALDH2 and ADH1B polymorphisms: Evidence from a meta-analysis and Mendelian randomization analysis. | 3 |
| 37875790 | 2023 | Genetic influences on alcohol flushing in East Asian populations. | 2 |
| 37985446 | 2023 | Association of TOP2A and ADH1B with lipid levels and prognosis in patients with lung adenocarcinoma and squamous cell carcinoma. | 1 |
| 38085522 | 2023 | Alcohol dehydrogenase-1B represses the proliferation, invasion and migration of breast cancer cells by inactivating the mitogen-activated protein kinase signalling pathway. | 1 |
| 35670037 | 2023 | Impacts of ADH1B rs1229984 and ALDH2 rs671 polymorphisms on risks of alcohol-related disorder and cancer. | 9 |
Citation
Dessen P
ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/582/adh1b
