ADM (adrenomedullin)

2003-08-01  

Identity

HGNC
LOCATION
11p15.4
LOCUSID
ALIAS
AM,PAMP
FUSION GENES

Other Information

Locus ID:

NCBI: 133
MIM: 103275
HGNC: 259
Ensembl: ENSG00000148926

Variants:

dbSNP: 133
ClinVar: 133
TCGA: ENSG00000148926
COSMIC: ADM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148926ENST00000278175P35318
ENSG00000148926ENST00000524948E9PML4
ENSG00000148926ENST00000525063P35318
ENSG00000148926ENST00000526492E9PQT2
ENSG00000148926ENST00000528544E9PML4
ENSG00000148926ENST00000528655P35318
ENSG00000148926ENST00000530439E9PQE6
ENSG00000148926ENST00000534464E9PL83

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Calcitonin-like ligand receptorsREACTOMER-HSA-419812
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA162390165GPR182GenePathwayassociated
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotationassociatedPD19636336
PA450801paroxetineChemicalClinicalAnnotationassociatedPD19636336

References

Pubmed IDYearTitleCitations
363103812023Overexpression of adrenomedullin (ADM) alleviates the senescence of human dental pulp stem cells by regulating the miR-152/CCNA2 pathway.1
364148822023Is adrenomedullin upregulation due to apical periodontitis independent of periodontal disease?0
371045562023Clinical Potential of Adrenomedullin Signaling in the Cardiovascular System.8
373119632023Impact of adrenomedullin on mitochondrial respiratory capacity in human adipocyte.0
378120532023Peptidylglycine α-amidating monooxygenase and adrenomedullin measurement in patients with hepatic cirrhosis.0
363103812023Overexpression of adrenomedullin (ADM) alleviates the senescence of human dental pulp stem cells by regulating the miR-152/CCNA2 pathway.1
364148822023Is adrenomedullin upregulation due to apical periodontitis independent of periodontal disease?0
371045562023Clinical Potential of Adrenomedullin Signaling in the Cardiovascular System.8
373119632023Impact of adrenomedullin on mitochondrial respiratory capacity in human adipocyte.0
378120532023Peptidylglycine α-amidating monooxygenase and adrenomedullin measurement in patients with hepatic cirrhosis.0
343426782022Proadrenomedullin and neonatal sepsis: a systematic review and meta-analysis of diagnostic accuracy.3
349904702022Association of circulating MR-proADM with all-cause and cardiovascular mortality in the general population: Results from the KORA F4 cohort study.6
350789912022Parallel functional assessment of m(6)A sites in human endodermal differentiation with base editor screens.4
353900312022Lipid dysfunction and adrenomedullin expression in omental versus subcutaneous adipose tissues in diabetic pregnancies.1
355836782022Plasma Adrenomedullin, Allelic Variations in the ADM Gene, and Risk for Lower-Limb Amputation in People With Type 2 Diabetes.0

Citation

Dessen P

ADM (adrenomedullin)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/584/adm