ADM (adrenomedullin)

2003-08-01  

Identity

HGNC
LOCATION
11p15.4
LOCUSID
ALIAS
AM,PAMP
FUSION GENES

Other Information

Locus ID:

NCBI: 133
MIM: 103275
HGNC: 259
Ensembl: ENSG00000148926

Variants:

dbSNP: 133
ClinVar: 133
TCGA: ENSG00000148926
COSMIC: ADM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148926ENST00000278175P35318
ENSG00000148926ENST00000524948E9PML4
ENSG00000148926ENST00000525063P35318
ENSG00000148926ENST00000526492E9PQT2
ENSG00000148926ENST00000528544E9PML4
ENSG00000148926ENST00000528655P35318
ENSG00000148926ENST00000530439E9PQE6
ENSG00000148926ENST00000534464E9PL83

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Calcitonin-like ligand receptorsREACTOMER-HSA-419812
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA162390165GPR182GenePathwayassociated
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotationassociatedPD19636336
PA450801paroxetineChemicalClinicalAnnotationassociatedPD19636336

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
207134992010Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression.69
219944142011Tumor-associated macrophages promote angiogenesis and melanoma growth via adrenomedullin in a paracrine and autocrine manner.53
229606552012Adrenomedullin is up-regulated in patients with pancreatic cancer and causes insulin resistance in β cells and mice.45
170530412007Receptor activity-modifying proteins: RAMPing up adrenomedullin signaling.34
128352242003Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells.32
121892262002The effects of adrenomedullin overexpression in breast tumor cells.31
157610412005Autocrine/paracrine role of inflammation-mediated calcitonin gene-related peptide and adrenomedullin expression in human adipose tissue.31
102252881999An investigation into the antimicrobial effects of adrenomedullin on members of the skin, oral, respiratory tract and gut microflora.30
180005972007Adrenomedullin and endothelial barrier function.30

Citation

Dessen P

ADM (adrenomedullin)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/584/adm