Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 135
MIM: 102776
HGNC: 263
Ensembl: ENSG00000128271
Variants:
dbSNP: 135
ClinVar: 135
TCGA: ENSG00000128271
COSMIC: ADORA2A
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443434 | Arthritis, Rheumatoid | Disease | ClinicalAnnotation | associated | PD | 18539621 | |
| PA446827 | Hematologic Neoplasms | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 27399166 | |
| PA446975 | Neurotoxicity Syndromes | Disease | VariantAnnotation | associated | PD | 27399166 | |
| PA447196 | Anxiety Disorders | Disease | ClinicalAnnotation | associated | PD | ||
| PA448710 | caffeine | Chemical | ClinicalAnnotation | associated | PD | 12825092, 17329997, 17616786, 18305461, 20520601, 22012471 | |
| PA450428 | methotrexate | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 18539621, 27399166 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38441967 | 2024 | CD8+ T cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione/GPX4. | 1 |
| 38522762 | 2024 | Blockade of endothelial adenosine receptor 2 A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition. | 0 |
| 38642131 | 2024 | A2AR-mediated CXCL5 upregulation on macrophages promotes NSCLC progression via NETosis. | 1 |
| 38731962 | 2024 | Clinical and Biologic Correlates of ADORA2A Transcriptomic Expression in Cancer. | 0 |
| 38892324 | 2024 | Genetic Polymorphisms of P2RX7 but Not of ADORA2A Are Associated with the Severity of SARS-CoV-2 Infection. | 0 |
| 38441967 | 2024 | CD8+ T cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione/GPX4. | 1 |
| 38522762 | 2024 | Blockade of endothelial adenosine receptor 2 A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition. | 0 |
| 38642131 | 2024 | A2AR-mediated CXCL5 upregulation on macrophages promotes NSCLC progression via NETosis. | 1 |
| 38731962 | 2024 | Clinical and Biologic Correlates of ADORA2A Transcriptomic Expression in Cancer. | 0 |
| 38892324 | 2024 | Genetic Polymorphisms of P2RX7 but Not of ADORA2A Are Associated with the Severity of SARS-CoV-2 Infection. | 0 |
| 34651389 | 2023 | Overexpression of LAG3, TIM3, and A2aR in adenoid cystic carcinoma and mucoepidermoid carcinoma. | 1 |
| 36053386 | 2023 | Adenosine A(2A) receptor availability in patients with early- and moderate-stage Parkinson's disease. | 2 |
| 36634866 | 2023 | Striatopallidal adenosine A(2A) receptor modulation of goal-directed behavior: Homeostatic control with cognitive flexibility. | 6 |
| 36637988 | 2023 | Comparative Study of Receptor-, Receptor State-, and Membrane-Dependent Cholesterol Binding Sites in A(2A) and A(1) Adenosine Receptors Using Coarse-Grained Molecular Dynamics Simulations. | 2 |
| 36835078 | 2023 | Increased Density of Endogenous Adenosine A(2A) Receptors in Atrial Fibrillation: From Cellular and Porcine Models to Human Patients. | 1 |
Citation
Dessen P
ADORA2A (adenosine A2a receptor)
Atlas Genet Cytogenet Oncol Haematol. 2007-12-01
Online version: http://atlasgeneticsoncology.org/gene/49956/adora2a
