ADORA2A (adenosine A2a receptor)

2007-12-01  

Identity

HGNC
LOCATION
22q11.23
LOCUSID
ALIAS
A2aR,ADORA2,RDC8

Other Information

Locus ID:

NCBI: 135
MIM: 102776
HGNC: 263
Ensembl: ENSG00000128271

Variants:

dbSNP: 135
ClinVar: 135
TCGA: ENSG00000128271
COSMIC: ADORA2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128271ENST00000337539P29274
ENSG00000128271ENST00000337539X5DNB4
ENSG00000128271ENST00000424232C9JFS2
ENSG00000128271ENST00000436735C9J3T2
ENSG00000128271ENST00000439591C9J0Z4
ENSG00000128271ENST00000444262C9JQD8
ENSG00000128271ENST00000472248S4R429
ENSG00000128271ENST00000486108S4R2Z8
ENSG00000128271ENST00000496258S4R3A7
ENSG00000128271ENST00000610595P29274
ENSG00000128271ENST00000610595X5DNB4
ENSG00000128271ENST00000611543P29274
ENSG00000128271ENST00000611543X5DNB4
ENSG00000128271ENST00000618076P29274
ENSG00000128271ENST00000618076X5DNB4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Parkinson's diseaseKEGGhsa05012
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Metabolism of proteinsREACTOMER-HSA-392499
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Activation of TRKA receptorsREACTOMER-HSA-187015
NGF-independant TRKA activationREACTOMER-HSA-187024
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Nucleotide-like (purinergic) receptorsREACTOMER-HSA-418038
Adenosine P1 receptorsREACTOMER-HSA-417973
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
Surfactant metabolismREACTOMER-HSA-5683826

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotationassociatedPD18539621
PA446827Hematologic NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationassociatedPD27399166
PA446975Neurotoxicity SyndromesDiseaseVariantAnnotationassociatedPD27399166
PA447196Anxiety DisordersDiseaseClinicalAnnotationassociatedPD
PA448710caffeineChemicalClinicalAnnotationassociatedPD12825092, 17329997, 17616786, 18305461, 20520601, 22012471
PA450428methotrexateChemicalClinicalAnnotation, VariantAnnotationassociatedPD18539621, 27399166

References

Pubmed IDYearTitleCitations
213935082011Structure of an agonist-bound human A2A adenosine receptor.315
215937632011Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation.288
227986132012Structural basis for allosteric regulation of GPCRs by sodium ions.285
218852912011Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine.158
129338192003Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer.131
274628122016Structure of the adenosine A(2A) receptor bound to an engineered G protein.118
195259442009Adenosine A(2A) receptor mediates microglial process retraction.99
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
271443522016Activation of the A2A adenosine G-protein-coupled receptor by conformational selection.76
128250922003Association between A2a receptor gene polymorphisms and caffeine-induced anxiety.66

Citation

Dessen P

ADORA2A (adenosine A2a receptor)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49956/adora2a