Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 148
MIM: 104221
HGNC: 277
Ensembl: ENSG00000120907
Variants:
dbSNP: 148
ClinVar: 148
TCGA: ENSG00000120907
COSMIC: ADRA1A
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164712344 | Alpha-adrenoreceptor antagonists | Chemical | Pathway | associated | |||
| PA444552 | Hypertension | Disease | ClinicalAnnotation | associated | PD | 19444285 | |
| PA449396 | dopamine | Chemical | Pathway | associated | |||
| PA449470 | epinephrine | Chemical | Pathway | associated | |||
| PA450121 | isoproterenol | Chemical | Pathway | associated | |||
| PA450431 | methoxamine | Chemical | Pathway | associated | |||
| PA450631 | nifedipine | Chemical | ClinicalAnnotation | associated | PD | 19444285 | |
| PA450649 | norepinephrine | Chemical | Pathway | associated | |||
| PA450935 | phenylephrine | Chemical | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36831252 | 2023 | Alpha1A- and Beta3-Adrenoceptors Interplay in Adipose Multipotent Mesenchymal Stromal Cells: A Novel Mechanism of Obesity-Driven Hypertension. | 2 |
| 37820700 | 2023 | Hsa_circ_0080608 Attenuates Lung Cancer Progression by Functioning as a Competitive Endogenous RNA to Regulate the miR-661/ADRA1A Pathway. | 1 |
| 36831252 | 2023 | Alpha1A- and Beta3-Adrenoceptors Interplay in Adipose Multipotent Mesenchymal Stromal Cells: A Novel Mechanism of Obesity-Driven Hypertension. | 2 |
| 37820700 | 2023 | Hsa_circ_0080608 Attenuates Lung Cancer Progression by Functioning as a Competitive Endogenous RNA to Regulate the miR-661/ADRA1A Pathway. | 1 |
| 34706275 | 2022 | MiR-3682 promotes the progression of hepatocellular carcinoma (HCC) via inactivating AMPK signaling by targeting ADRA1A. | 2 |
| 35964682 | 2022 | Hypermethylation in the promoter region of the ADRA1A gene is associated with opioid use disorder in Han Chinese. | 1 |
| 36012699 | 2022 | Vascular Reactions of the Diving Reflex in Men and Women Carrying Different ADRA1A Genotypes. | 1 |
| 34706275 | 2022 | MiR-3682 promotes the progression of hepatocellular carcinoma (HCC) via inactivating AMPK signaling by targeting ADRA1A. | 2 |
| 35964682 | 2022 | Hypermethylation in the promoter region of the ADRA1A gene is associated with opioid use disorder in Han Chinese. | 1 |
| 36012699 | 2022 | Vascular Reactions of the Diving Reflex in Men and Women Carrying Different ADRA1A Genotypes. | 1 |
| 33577997 | 2021 | Association study of Catechol-o-methyltransferase and Alpha-1-adrenergic receptor gene polymorphisms with multiple phenotypes of heroin use disorder. | 3 |
| 34032285 | 2021 | Class A G protein-coupled receptors assemble into functional higher-order hetero-oligomers. | 7 |
| 34284799 | 2021 | Role of α- and β-adrenergic signaling in phenotypic targeting: significance in benign and malignant urologic disease. | 7 |
| 34301959 | 2021 | Deacetylation as a receptor-regulated direct activation switch for pannexin channels. | 7 |
| 33577997 | 2021 | Association study of Catechol-o-methyltransferase and Alpha-1-adrenergic receptor gene polymorphisms with multiple phenotypes of heroin use disorder. | 3 |
Citation
Dessen P
ADRA1A (adrenoceptor alpha 1A)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45787/adra1a
