Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 147
MIM: 104220
HGNC: 278
Ensembl: ENSG00000170214
Variants:
dbSNP: 147
ClinVar: 147
TCGA: ENSG00000170214
COSMIC: ADRA1B
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000170214 | ENST00000306675 | P35368 |
| ENSG00000170214 | ENST00000641205 | A0A286YF88 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164712344 | Alpha-adrenoreceptor antagonists | Chemical | Pathway | associated | |||
| PA449396 | dopamine | Chemical | Pathway | associated | |||
| PA449470 | epinephrine | Chemical | Pathway | associated | |||
| PA450121 | isoproterenol | Chemical | Pathway | associated | |||
| PA450431 | methoxamine | Chemical | Pathway | associated | |||
| PA450649 | norepinephrine | Chemical | Pathway | associated | |||
| PA450935 | phenylephrine | Chemical | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37394637 | 2023 | L-DOPA Receptor GPR143 Functionally Couples with Adrenergic α(1B) Receptor at the Second Transmembrane Interface. | 0 |
| 37394637 | 2023 | L-DOPA Receptor GPR143 Functionally Couples with Adrenergic α(1B) Receptor at the Second Transmembrane Interface. | 0 |
| 34958868 | 2022 | PKC-isoform specific regulation of receptor desensitization and KCNQ1/KCNE1 K(+) channel activity by mutant α(1B)-adrenergic receptors. | 0 |
| 34958868 | 2022 | PKC-isoform specific regulation of receptor desensitization and KCNQ1/KCNE1 K(+) channel activity by mutant α(1B)-adrenergic receptors. | 0 |
| 31520851 | 2020 | Tumor necrosis factor α induces α(1B)-adrenergic receptor expression in keratinocytes. | 3 |
| 31811856 | 2020 | Roles of the G protein-coupled receptor kinase 2 and Rab5 in α(1B)-adrenergic receptor function and internalization. | 1 |
| 32085899 | 2020 | Characterization of heteromeric complexes between chemokine (C-X-C motif) receptor 4 and α(1)-adrenergic receptors utilizing intermolecular bioluminescence resonance energy transfer assays. | 9 |
| 31520851 | 2020 | Tumor necrosis factor α induces α(1B)-adrenergic receptor expression in keratinocytes. | 3 |
| 31811856 | 2020 | Roles of the G protein-coupled receptor kinase 2 and Rab5 in α(1B)-adrenergic receptor function and internalization. | 1 |
| 32085899 | 2020 | Characterization of heteromeric complexes between chemokine (C-X-C motif) receptor 4 and α(1)-adrenergic receptors utilizing intermolecular bioluminescence resonance energy transfer assays. | 9 |
| 30785334 | 2019 | Fine mapping and subphenotyping implicates ADRA1B gene variants in psoriasis susceptibility in a Chinese population. | 5 |
| 30862702 | 2019 | Mutations in the NPxxY motif stabilize pharmacologically distinct conformational states of the α(1B)- and β(2)-adrenoceptors. | 11 |
| 30785334 | 2019 | Fine mapping and subphenotyping implicates ADRA1B gene variants in psoriasis susceptibility in a Chinese population. | 5 |
| 30862702 | 2019 | Mutations in the NPxxY motif stabilize pharmacologically distinct conformational states of the α(1B)- and β(2)-adrenoceptors. | 11 |
| 29089212 | 2018 | Up-regulation of α(1)-adrenoceptors in burn and keloid scars. | 7 |
Citation
Dessen P
ADRA1B (adrenoceptor alpha 1B)
Atlas Genet Cytogenet Oncol Haematol. 2003-12-01
Online version: http://atlasgeneticsoncology.org/gene/589/adra1b
