ADRA2A (adrenoceptor alpha 2A)

2015-05-01  

Identity

HGNC
LOCATION
10q25.2
LOCUSID
ALIAS
ADRA2,ADRA2R,ADRAR,ALPHA2AAR,ZNF32

Other Information

Locus ID:

NCBI: 150
MIM: 104210
HGNC: 281
Ensembl: ENSG00000150594

Variants:

dbSNP: 150
ClinVar: 150
TCGA: ENSG00000150594
COSMIC: ADRA2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000150594ENST00000280155P08913

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
Metabolism of proteinsREACTOMER-HSA-392499
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Platelet Aggregation (Plug Formation)REACTOMER-HSA-76009
Adrenaline signalling through Alpha-2 adrenergic receptorREACTOMER-HSA-392023
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
AdrenoceptorsREACTOMER-HSA-390696
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (z) signalling eventsREACTOMER-HSA-418597
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356
Adrenaline,noradrenaline inhibits insulin secretionREACTOMER-HSA-400042
Surfactant metabolismREACTOMER-HSA-5683826

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164713257Selective serotonin reuptake inhibitorsChemicalClinicalAnnotationassociatedPD25642918
PA164752812milnacipranChemicalClinicalAnnotationassociatedPD
PA445208PainDiseaseVariantAnnotationnot associatedPD21398039
PA445210Pain, PostoperativeDiseaseClinicalAnnotationassociatedPD
PA446479Hypertrophy, Left VentricularDiseaseClinicalAnnotationassociatedPD15614026
PA447197Attention Deficit Disorder with HyperactivityDiseaseClinicalAnnotation, VariantAnnotationambiguousPD17283289, 18200436, 19150055, 21103886, 23609393, 29230023
PA447207Depressive DisorderDiseaseClinicalAnnotationassociatedPD
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotationassociatedPD25642918
PA448499atenololChemicalClinicalAnnotationassociatedPD15614026
PA448665brimonidineChemicalPathwayassociated
PA449051clonidineChemicalPathwayassociated
PA449256dexmedetomidineChemicalClinicalAnnotationassociatedPD21104443
PA449396dopamineChemicalPathwayassociated
PA449470epinephrineChemicalPathwayassociated
PA450121isoproterenolChemicalPathwayassociated
PA450464methylphenidateChemicalClinicalAnnotation, VariantAnnotationambiguousPD17283289, 18200436, 19150055, 21103886, 23609393, 29230023
PA450649norepinephrineChemicalPathwayassociated
PA451946yohimbineChemicalPathwayassociated
PA452618opioidsChemicalVariantAnnotationnot associatedPD21398039

References

Pubmed IDYearTitleCitations
200818582010New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.925
195069062009Candidate gene studies of ADHD: a meta-analytic review.263
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
199653902010Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes.84
205263382010Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.84
151382092004Association of distinct alpha(2) adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders.58
150709582004Estrogen controls lipolysis by up-regulating alpha2A-adrenergic receptors directly in human adipose tissue through the estrogen receptor alpha. Implications for the female fat distribution.55
171590892007Population-based sample reveals gene-gender interactions in blood pressure in White Americans.54
157172912005Support for association between ADHD and two candidate genes: NET1 and DRD1.53

Citation

Dessen P

ADRA2A (adrenoceptor alpha 2A)

Atlas Genet Cytogenet Oncol Haematol. 2015-05-01

Online version: http://atlasgeneticsoncology.org/gene/55181/adra2a