ADRA2C (adrenoceptor alpha 2C)

2012-03-01 Affiliation

Identity

HGNC

ADRA2C

LOCATION

4p16.3

LOCUSID

152

ALIAS

ADRA2L2,ADRA2RL2,ADRARL2,ALPHA2CAR

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 152
MIM: 104250
HGNC: 283
Ensembl: ENSG00000184160

Variants:

dbSNP: 152
ClinVar: 152
TCGA: ENSG00000184160
COSMIC: ADRA2C

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000184160	ENST00000330055	P18825
ENSG00000184160	ENST00000330055	Q4W594
ENSG00000184160	ENST00000509482	D6RGL0

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
cGMP-PKG signaling pathway	KEGG	hsa04022
cGMP-PKG signaling pathway	KEGG	ko04022
Metabolism of proteins	REACTOME	R-HSA-392499
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Platelet Aggregation (Plug Formation)	REACTOME	R-HSA-76009
Adrenaline signalling through Alpha-2 adrenergic receptor	REACTOME	R-HSA-392023
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Amine ligand-binding receptors	REACTOME	R-HSA-375280
Adrenoceptors	REACTOME	R-HSA-390696
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594
G alpha (z) signalling events	REACTOME	R-HSA-418597
Metabolism	REACTOME	R-HSA-1430728
Integration of energy metabolism	REACTOME	R-HSA-163685
Regulation of insulin secretion	REACTOME	R-HSA-422356
Adrenaline,noradrenaline inhibits insulin secretion	REACTOME	R-HSA-400042
Surfactant metabolism	REACTOME	R-HSA-5683826

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA165945764	bucindolol	Chemical	ClinicalAnnotation	associated	PD	23071495
PA444370	Heart Failure	Disease	ClinicalAnnotation	associated	PD	23071495
PA444797	Liver Cirrhosis	Disease	ClinicalAnnotation	associated	PD	20833658
PA448665	brimonidine	Chemical	Pathway	associated
PA449051	clonidine	Chemical	ClinicalAnnotation, Pathway	associated	PD	20833658
PA449396	dopamine	Chemical	Pathway	associated
PA449470	epinephrine	Chemical	Pathway	associated
PA450121	isoproterenol	Chemical	Pathway	associated
PA450649	norepinephrine	Chemical	Pathway	associated
PA451946	yohimbine	Chemical	Pathway	associated

References

Pubmed ID	Year	Title	Citations
12374873	2002	Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure.	100
19874574	2009	Genetical genomic determinants of alcohol consumption in rats and humans.	93
18702968	2008	Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol.	52
21041608	2011	Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up.	48
19880803	2010	An alpha2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure.	38
19880803	2010	An alpha2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure.	38
16464220	2006	A study of candidate genotypes associated with dyspepsia in a U.S. community.	37
18308161	2008	Neural control of heart rate is an arrhythmia risk modifier in long QT syndrome.	34
17496726	2007	Synergistic polymorphisms of beta1 and alpha2C-adrenergic receptors and the influence on left ventricular ejection fraction response to beta-blocker therapy in heart failure.	33
17223428	2007	Relation of beta(2)-adrenoceptor haplotype to risk of death and heart transplantation in patients with heart failure.	32

Citation

Dessen P

ADRA2C (adrenoceptor alpha 2C)

Atlas Genet Cytogenet Oncol Haematol. 2012-03-01

Online version: http://atlasgeneticsoncology.org/gene/52616/adra2c