ADTRP (androgen dependent TFPI regulating protein)

2014-11-01  

Identity

HGNC
ADTRP
LOCATION
6p24.1
LOCUSID
84830
ALIAS
AIG1L,C6orf105,dJ413H6.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84830
MIM: 614348
HGNC: 21214
Ensembl: ENSG00000111863

Variants:

dbSNP: 84830
ClinVar: 84830
TCGA: ENSG00000111863
COSMIC: ADTRP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111863ENST00000229583Q96IZ2
ENSG00000111863ENST00000379415D6R9A9
ENSG00000111863ENST00000414691Q96IZ2
ENSG00000111863ENST00000485323D6RDG9
ENSG00000111863ENST00000503285H0YAA5
ENSG00000111863ENST00000505099H0Y9P4
ENSG00000111863ENST00000506810D6R9A9

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
218685742011Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen.31
164151752006High throughput SNP and expression analyses of candidate genes for non-syndromic oral clefts.17
245730172014Associations between the CDKN2A/B, ADTRP and PDGFD polymorphisms and the development of coronary atherosclerosis in Japanese patients.16
270188882016AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs.15
233376892013Association of single nucleotide polymorphism rs6903956 on chromosome 6p24.1 with coronary artery disease and lipid levels in different ethnic groups of the Singaporean population.13
255954572015The coronary artery disease-associated gene C6ORF105 is expressed in human macrophages under the transcriptional control of PPARγ.8
283415522017Identification of a molecular signaling gene-gene regulatory network between GWAS susceptibility genes ADTRP and MIA3/TANGO1 for coronary artery disease.8
263759202015Common Variants in Promoter of ADTRP Associate with Early-Onset Coronary Artery Disease in a Southern Han Chinese Population.7
272354492016Coronary artery disease susceptibility gene ADTRP regulates cell cycle progression, proliferation, and apoptosis by global gene expression regulation.7

Citation

Dessen P

ADTRP (androgen dependent TFPI regulating protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60177/adtrp