AGMAT (agmatinase)

2012-12-01  

Identity

HGNC
LOCATION
1p36.21
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 79814
MIM: 617887
HGNC: 18407
Ensembl: ENSG00000116771

Variants:

dbSNP: 79814
ClinVar: 79814
TCGA: ENSG00000116771
COSMIC: AGMAT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116771ENST00000375826Q9BSE5
ENSG00000116771ENST00000375826A0A024QZ78

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
Arginine and proline metabolismKEGGhsa00330
Metabolic pathwaysKEGGhsa01100
Polyamine biosynthesis, arginine => agmatine => putrescine => spermidineKEGGhsa_M00133
Polyamine biosynthesis, arginine => agmatine => putrescine => spermidineKEGGM00133
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Metabolism of polyaminesREACTOMER-HSA-351202
Agmatine biosynthesisREACTOMER-HSA-351143

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
367048512023miR‑151a‑5p promotes the proliferation and metastasis of colorectal carcinoma cells by targeting AGMAT.4
367048512023miR‑151a‑5p promotes the proliferation and metastasis of colorectal carcinoma cells by targeting AGMAT.4
316999972019Agmatinase promotes the lung adenocarcinoma tumorigenesis by activating the NO-MAPKs-PI3K/Akt pathway.22
316999972019Agmatinase promotes the lung adenocarcinoma tumorigenesis by activating the NO-MAPKs-PI3K/Akt pathway.22
237405192013Enzymes of urea synthesis are expressed at the ocular surface, and decreased urea in the tear fluid is associated with dry-eye syndrome.4
237405192013Enzymes of urea synthesis are expressed at the ocular surface, and decreased urea in the tear fluid is associated with dry-eye syndrome.4
218030592012Agmatinase, an inactivator of the putative endogenous antidepressant agmatine, is strongly upregulated in hippocampal interneurons of subjects with mood disorders.14
218030592012Agmatinase, an inactivator of the putative endogenous antidepressant agmatine, is strongly upregulated in hippocampal interneurons of subjects with mood disorders.14
205638782011The agmatine-degrading enzyme agmatinase: a key to agmatine signaling in rat and human brain?10
205638782011The agmatine-degrading enzyme agmatinase: a key to agmatine signaling in rat and human brain?10
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
208088252010Novel association strategy with copy number variation for identifying new risk Loci of human diseases.14
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
208088252010Novel association strategy with copy number variation for identifying new risk Loci of human diseases.14

Citation

Dessen P

AGMAT (agmatinase)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53087/agmat