AGO1 (argonaute RISC component 1)

2010-03-01  

Identity

HGNC
LOCATION
1p34.3
LOCUSID
ALIAS
EIF2C,EIF2C1,GERP95,Q99,hAgo1
FUSION GENES

Other Information

Locus ID:

NCBI: 26523
MIM: 606228
HGNC: 3262
Ensembl: ENSG00000092847

Variants:

dbSNP: 26523
ClinVar: 26523
TCGA: ENSG00000092847
COSMIC: AGO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000092847ENST00000373204Q9UL18
ENSG00000092847ENST00000373206Q5TA58
ENSG00000092847ENST00000635259A0A0U1RQZ8

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)REACTOMER-HSA-1168372
PIP3 activates AKT signalingREACTOMER-HSA-1257604
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
Role of LAT2/NTAL/LAB on calcium mobilizationREACTOMER-HSA-2730905
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
GAB1 signalosomeREACTOMER-HSA-180292
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
PI3K/AKT activationREACTOMER-HSA-198203
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by SCF-KITREACTOMER-HSA-1433557
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK6/MAPK4 signalingREACTOMER-HSA-5687128
Signaling by NOTCHREACTOMER-HSA-157118
Pre-NOTCH Expression and ProcessingREACTOMER-HSA-1912422
Pre-NOTCH Transcription and TranslationREACTOMER-HSA-1912408
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
Ca2+ pathwayREACTOMER-HSA-4086398
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
Gene Silencing by RNAREACTOMER-HSA-211000
MicroRNA (miRNA) biogenesisREACTOMER-HSA-203927
Small interfering RNA (siRNA) biogenesisREACTOMER-HSA-426486
Post-transcriptional silencing by small RNAsREACTOMER-HSA-426496
Transcriptional regulation by small RNAsREACTOMER-HSA-5578749
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oncogene Induced SenescenceREACTOMER-HSA-2559585
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580

References

Pubmed IDYearTitleCitations
151522572004Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain.242
169367262006Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells.185
183450152008GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay.176
179325092007Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.166
169367282006Involvement of AGO1 and AGO2 in mammalian transcriptional silencing.149
229613792012Argonaute proteins couple chromatin silencing to alternative splicing.107
178911502007A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain.100
190471282008Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.99
191389932008Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk.95
228586792012Distinct AGO1 and AGO2 associated miRNA profiles in human cells and blood plasma.88

Citation

Dessen P

AGO1 (argonaute RISC component 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/52819/ago1