AGPAT3 (1-acylglycerol-3-phosphate O-acyltransferase 3)

2014-11-01  

Identity

HGNC
AGPAT3
LOCATION
21q22.3
LOCUSID
56894
ALIAS
1-AGPAT 3,LPAAT-GAMMA1,LPAAT3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56894
MIM: 614794
HGNC: 326
Ensembl: ENSG00000160216

Variants:

dbSNP: 56894
ClinVar: 56894
TCGA: ENSG00000160216
COSMIC: AGPAT3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160216ENST00000291572Q9NRZ7
ENSG00000160216ENST00000327505Q9NRZ7
ENSG00000160216ENST00000398058Q9NRZ7
ENSG00000160216ENST00000398061Q9NRZ7
ENSG00000160216ENST00000398063Q9NRZ7
ENSG00000160216ENST00000422850C9JL26
ENSG00000160216ENST00000445582C9J184
ENSG00000160216ENST00000448287C9JQX8
ENSG00000160216ENST00000448845C9JK35
ENSG00000160216ENST00000457068C9JL26
ENSG00000160216ENST00000546158Q9NRZ7

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycerolipid metabolismKEGGko00561
Glycerophospholipid metabolismKEGGko00564
Glycerolipid metabolismKEGGhsa00561
Glycerophospholipid metabolismKEGGhsa00564
Metabolic pathwaysKEGGhsa01100
Triacylglycerol biosynthesisKEGGhsa_M00089
Triacylglycerol biosynthesisKEGGM00089
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Synthesis of PAREACTOMER-HSA-1483166
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-independent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811436

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
196358402009Lysophosphatidic acid acyltransferase 3 regulates Golgi complex structure and function.35
211731902011Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria.21
166207712006Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity.20
205379802010Membrane topology of human AGPAT3 (LPAAT3).11

Citation

Dessen P

AGPAT3 (1-acylglycerol-3-phosphate O-acyltransferase 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60204/agpat3