AGRP (agouti related neuropeptide)

2015-02-01  

Identity

HGNC
LOCATION
16q22.1
LOCUSID
ALIAS
AGRT,ART,ASIP2

Other Information

Locus ID:

NCBI: 181
MIM: 602311
HGNC: 330
Ensembl: ENSG00000159723

Variants:

dbSNP: 181
ClinVar: 181
TCGA: ENSG00000159723
COSMIC: AGRP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159723ENST00000290953O00253
ENSG00000159723ENST00000290953C6SUN5

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Adipocytokine signaling pathwayKEGGko04920
Adipocytokine signaling pathwayKEGGhsa04920

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
197701862009Hormone and glucose signalling in POMC and AgRP neurons.66
204680642010Association study of 182 candidate genes in anorexia nervosa.30
155971102005Melanocortin-4 receptor gene and physical activity in the Québec Family Study.29
113263032001Association between an agouti-related protein gene polymorphism and anorexia nervosa.28
239004452014Genetic association analysis of 30 genes related to obesity in a European American population.26
171971062007Family trios analysis of common polymorphisms in the obestatin/ghrelin, BDNF and AGRP genes in patients with Anorexia nervosa: association with subtype, body-mass index, severity and age of onset.25
170412502006The natural inverse agonist agouti-related protein induces arrestin-mediated endocytosis of melanocortin-3 and -4 receptors.23
117474272001High-resolution NMR structure of the chemically-synthesized melanocortin receptor binding domain AGRP(87-132) of the agouti-related protein.20
190587892009A common variant in DRD3 receptor is associated with autism spectrum disorder.19
114877442001Mutational analysis of melanocortin-4 receptor, agouti-related protein, and alpha-melanocyte-stimulating hormone genes in severely obese children.17

Citation

Dessen P

AGRP (agouti related neuropeptide)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/55051/agrp