AHR (aryl hydrocarbon receptor)

2003-08-01  

Identity

HGNC
LOCATION
7p21.1
LOCUSID
ALIAS
RP85,bHLHe76
FUSION GENES

Other Information

Locus ID:

NCBI: 196
MIM: 600253
HGNC: 348
Ensembl: ENSG00000106546

Variants:

dbSNP: 196
ClinVar: 196
TCGA: ENSG00000106546
COSMIC: AHR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106546ENST00000242057P35869
ENSG00000106546ENST00000242057A0A024R9Z8
ENSG00000106546ENST00000463496P35869
ENSG00000106546ENST00000463496A0A024R9Z8
ENSG00000106546ENST00000642825A0A2R8Y7G1

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
Endogenous sterolsREACTOMER-HSA-211976
XenobioticsREACTOMER-HSA-211981
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659
Aryl hydrocarbon receptor signallingREACTOMER-HSA-8937144

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA165816878methylcholanthreneChemicalVipGeneassociated17481570
PA166157322rs2066853VariantVipGeneassociated11207035, 11505220, 11866883, 12852830, 15860653, 7550366, 10739168
PA447215Psychotic DisordersDiseaseClinicalAnnotationassociatedPK23492908
PA450688olanzapineChemicalClinicalAnnotationassociatedPK23492908
PA450704omeprazoleChemicalVariantAnnotationassociatedPK15860653
PA452604xenobioticsChemicalVariantAnnotationambiguousPK11207035, 15860653

References

Pubmed IDYearTitleCitations
219760232011An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor.447
191146682009Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells.193
173927872007Dioxin receptor is a ligand-dependent E3 ubiquitin ligase.158
127741242003Modulation of oestrogen receptor signalling by association with the activated dioxin receptor.142
216002062011Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract.130
206760922010Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells.129
260058552015Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α.123
178233042007RelB, a new partner of aryl hydrocarbon receptor-mediated transcription.109
256573512015The aryl hydrocarbon receptor in barrier organ physiology, immunology, and toxicology.109
175026242007Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation.104

Citation

Dessen P

AHR (aryl hydrocarbon receptor)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/598/ahr