AIF1 (allograft inflammatory factor 1)

2007-07-01  

Identity

HGNC
LOCATION
6p21.33
LOCUSID
ALIAS
AIF-1,IBA1,IRT-1,IRT1
FUSION GENES

Other Information

Locus ID:

NCBI: 199
MIM: 601833
HGNC: 352
Ensembl: ENSG00000204472

Variants:

dbSNP: 199
ClinVar: 199
TCGA: ENSG00000204472
COSMIC: AIF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204472ENST00000337917Q5STX8
ENSG00000204472ENST00000376049P55008
ENSG00000204472ENST00000376049I3WTX1
ENSG00000204472ENST00000376059P55008
ENSG00000204472ENST00000376059Q4V347

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
192047262009Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.63
198514452009High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.51
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
183416532008Daintain/AIF-1 promotes breast cancer proliferation via activation of the NF-kappaB/cyclin D1 pathway and facilitates tumor growth.23
127145652003AIF-1 is an actin-polymerizing and Rac1-activating protein that promotes vascular smooth muscle cell migration.19
162918192006Inhibition of AIF-1 expression by constitutive siRNA expression reduces macrophage migration, proliferation, and signal transduction initiated by atherogenic stimuli.18
208555362010Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma.18
217204442012Common variants in FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 show evidence of association with adult obesity in the Greek population.17
175220982007An allograft inflammatory factor 1 (AIF1) single nucleotide polymorphism (SNP) is associated with anticentromere antibody positive systemic sclerosis.16
175220982007An allograft inflammatory factor 1 (AIF1) single nucleotide polymorphism (SNP) is associated with anticentromere antibody positive systemic sclerosis.16

Citation

Dessen P

AIF1 (allograft inflammatory factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47623/aif1