AIMP2 (aminoacyl tRNA synthetase complex interacting multifunctional protein 2)

2012-12-01  

Identity

HGNC
LOCATION
7p22.1
LOCUSID
ALIAS
HLD17,JTV-1,JTV1,P38
FUSION GENES

Other Information

Locus ID:

NCBI: 7965
MIM: 600859
HGNC: 20609
Ensembl: ENSG00000106305

Variants:

dbSNP: 7965
ClinVar: 7965
TCGA: ENSG00000106305
COSMIC: AIMP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106305ENST00000223029Q13155
ENSG00000106305ENST00000223029A0A024QZY1
ENSG00000106305ENST00000395236Q13155
ENSG00000106305ENST00000400479A8MU58
ENSG00000106305ENST00000415999F8WCL2

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
tRNA AminoacylationREACTOMER-HSA-379724
Cytosolic tRNA aminoacylationREACTOMER-HSA-379716
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Selenoamino acid metabolismREACTOMER-HSA-2408522
SeMet incorporation into proteinsREACTOMER-HSA-2408517

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
239747092013Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss.62
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.25
214838032011Cancer-associated splicing variant of tumor suppressor AIMP2/p38: pathological implication in tumorigenesis.23
225326252012Splicing variant of AIMP2 as an effective target against chemoresistant ovarian cancer.16
253203102015Interaction of NS2 with AIMP2 facilitates the switch from ubiquitination to SUMOylation of M1 in influenza A virus-infected cells.16
264729282015Assembly of Multi-tRNA Synthetase Complex via Heterotetrameric Glutathione Transferase-homology Domains.15
196251762009PTEN identified as important risk factor of chronic obstructive pulmonary disease.12
283835622017VPS35 regulates parkin substrate AIMP2 toxicity by facilitating lysosomal clearance of AIMP2.8
292150952018Homozygosity for a nonsense variant in AIMP2 is associated with a progressive neurodevelopmental disorder with microcephaly, seizures, and spastic quadriparesis.6

Citation

Dessen P

AIMP2 (aminoacyl tRNA synthetase complex interacting multifunctional protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53099/aimp2