AKR1B15 (aldo-keto reductase family 1 member B15)

2014-11-01  

Identity

HGNC
AKR1B15
LOCATION
7q33
LOCUSID
441282
ALIAS
AKR1B10L,AKR1B10L, AK1R1B7,AKR1R1B7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 441282
MIM: 616336
HGNC: 37281
Ensembl: ENSG00000227471

Variants:

dbSNP: 441282
ClinVar: 441282
TCGA: ENSG00000227471
COSMIC: AKR1B15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000227471ENST00000423958C9JRZ8
ENSG00000227471ENST00000457545C9JRZ8
ENSG00000227471ENST00000652743C9JRZ8

Expression (GTEx)

0
1
2
3
4
5
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Metabolism of steroid hormonesREACTOMER-HSA-196071
Estrogen biosynthesisREACTOMER-HSA-193144

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
222779672012Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing.141
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
212767822011Functional expression of novel human and murine AKR1B genes.0
229708572013Identification of a role for a mouse sperm surface aldo-keto reductase (AKR1B7) and its human analogue in the detoxification of the reactive aldehyde, acrolein.0
255774932015Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates.0
262224392015Substrate Specificity, Inhibitor Selectivity and Structure-Function Relationships of Aldo-Keto Reductase 1B15: A Novel Human Retinaldehyde Reductase.0

Citation

Dessen P

AKR1B15 (aldo-keto reductase family 1 member B15)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60230/akr1b15