Identity
HGNC
LOCATION
15q21.3
LOCUSID
ALIAS
RALDH(II),RALDH2,RALDH2-T
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8854
MIM: 603687
HGNC: 15472
Ensembl: ENSG00000128918
Variants:
dbSNP: 8854
ClinVar: 8854
TCGA: ENSG00000128918
COSMIC: ALDH1A2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164712563 | Bisphosphonates | Chemical | ClinicalAnnotation | associated | PD | ||
| PA444552 | Hypertension | Disease | ClinicalAnnotation | associated | PD | 29097388 | |
| PA445187 | Osteonecrosis | Disease | ClinicalAnnotation | associated | PD | ||
| PA448499 | atenolol | Chemical | ClinicalAnnotation | associated | PD | 29097388 | |
| PA449899 | hydrochlorothiazide | Chemical | ClinicalAnnotation | associated | PD | 29097388 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38441233 | 2024 | A functional variant of ALDH1A2 is associated with hand osteoarthritis in the Chinese population. | 0 |
| 38441233 | 2024 | A functional variant of ALDH1A2 is associated with hand osteoarthritis in the Chinese population. | 0 |
| 36263470 | 2023 | ALDH1A2-related disorder: A new genetic syndrome due to alteration of the retinoic acid pathway. | 3 |
| 36263470 | 2023 | ALDH1A2-related disorder: A new genetic syndrome due to alteration of the retinoic acid pathway. | 3 |
| 35059888 | 2022 | An eQTL variant of ALDH1A2 is associated with Kashin-Beck disease in Chinese population. | 0 |
| 35059888 | 2022 | An eQTL variant of ALDH1A2 is associated with Kashin-Beck disease in Chinese population. | 0 |
| 33378690 | 2021 | Peanut protein acts as a T(H)2 adjuvant by inducing RALDH2 in human antigen-presenting cells. | 8 |
| 34572134 | 2021 | The Presence and Potential Role of ALDH1A2 in the Glioblastoma Microenvironment. | 5 |
| 33378690 | 2021 | Peanut protein acts as a T(H)2 adjuvant by inducing RALDH2 in human antigen-presenting cells. | 8 |
| 34572134 | 2021 | The Presence and Potential Role of ALDH1A2 in the Glioblastoma Microenvironment. | 5 |
| 31923393 | 2020 | Structural and kinetic features of aldehyde dehydrogenase 1A (ALDH1A) subfamily members, cancer stem cell markers active in retinoic acid biosynthesis. | 17 |
| 31923393 | 2020 | Structural and kinetic features of aldehyde dehydrogenase 1A (ALDH1A) subfamily members, cancer stem cell markers active in retinoic acid biosynthesis. | 17 |
| 29732726 | 2018 | Functional Characterization of the Osteoarthritis Genetic Risk Residing at ALDH1A2 Identifies rs12915901 as a Key Target Variant. | 22 |
| 29732726 | 2018 | Functional Characterization of the Osteoarthritis Genetic Risk Residing at ALDH1A2 Identifies rs12915901 as a Key Target Variant. | 22 |
| 27643404 | 2017 | Alcohol consumption and prostate cancer incidence and progression: A Mendelian randomisation study. | 19 |
Citation
Dessen P
ALDH1A2 (aldehyde dehydrogenase 1 family member A2)
Atlas Genet Cytogenet Oncol Haematol. 2012-12-01
Online version: http://atlasgeneticsoncology.org/gene/53100/aldh1a2
