ALDH3B1 (aldehyde dehydrogenase 3 family member B1)

2014-11-01 Affiliation

Identity

HGNC

ALDH3B1

LOCATION

11q13.2

LOCUSID

221

ALIAS

ALDH4,ALDH7

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 221
MIM: 600466
HGNC: 410
Ensembl: ENSG00000006534

Variants:

dbSNP: 221
ClinVar: 221
TCGA: ENSG00000006534
COSMIC: ALDH3B1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000006534	ENST00000342456	P43353
ENSG00000006534	ENST00000342456	A0A024R5D8
ENSG00000006534	ENST00000527514	A0A087WU54
ENSG00000006534	ENST00000612297	A0A087X2D4
ENSG00000006534	ENST00000614849	P43353
ENSG00000006534	ENST00000614849	A0A024R5D8
ENSG00000006534	ENST00000615463	Q9BUJ8
ENSG00000006534	ENST00000616697	A0A087WTE0
ENSG00000006534	ENST00000617288	P43353
ENSG00000006534	ENST00000617288	A0A024R5K0
ENSG00000006534	ENST00000617449	A0A087X192
ENSG00000006534	ENST00000619675	A0A087WUF8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glycolysis / Gluconeogenesis	KEGG	ko00010
Histidine metabolism	KEGG	ko00340
Tyrosine metabolism	KEGG	ko00350
Phenylalanine metabolism	KEGG	ko00360
beta-Alanine metabolism	KEGG	ko00410
Metabolism of xenobiotics by cytochrome P450	KEGG	ko00980
Drug metabolism - cytochrome P450	KEGG	ko00982
Glycolysis / Gluconeogenesis	KEGG	hsa00010
Histidine metabolism	KEGG	hsa00340
Tyrosine metabolism	KEGG	hsa00350
Phenylalanine metabolism	KEGG	hsa00360
beta-Alanine metabolism	KEGG	hsa00410
Metabolism of xenobiotics by cytochrome P450	KEGG	hsa00980
Drug metabolism - cytochrome P450	KEGG	hsa00982
Metabolic pathways	KEGG	hsa01100
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Sphingolipid metabolism	REACTOME	R-HSA-428157
Sphingolipid de novo biosynthesis	REACTOME	R-HSA-1660661
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA443890	Diabetes Mellitus, Type 2	Disease	Literature, MultilinkAnnotation	associated			24595071

References

Pubmed ID	Year	Title	Citations
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	27
20729348	2010	Aldehyde dehydrogenase 3B1 (ALDH3B1): immunohistochemical tissue distribution and cellular-specific localization in normal and cancerous human tissues.	19
17382292	2007	Expression and initial characterization of human ALDH3B1.	15
17382292	2007	Expression and initial characterization of human ALDH3B1.	15
20699116	2010	Molecular characterization, expression analysis, and role of ALDH3B1 in the cellular protection against oxidative stress.	11
23721920	2013	Substrate specificity, plasma membrane localization, and lipid modification of the aldehyde dehydrogenase ALDH3B1.	11
19159868	2009	Evidence of epistasis between the catechol-O-methyltransferase and aldehyde dehydrogenase 3B1 genes in paranoid schizophrenia.	8
19159868	2009	Evidence of epistasis between the catechol-O-methyltransferase and aldehyde dehydrogenase 3B1 genes in paranoid schizophrenia.	8
16092759	2005	Multi-locus association study of schizophrenia susceptibility genes with a posterior probability method.	4
19343046	2009	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	3

Citation

Dessen P

ALDH3B1 (aldehyde dehydrogenase 3 family member B1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60242/aldh3b1