ALDOC (aldolase, fructose-bisphosphate C)

2007-04-01  

Identity

HGNC
ALDOC
LOCATION
17q11.2
LOCUSID
230
ALIAS
ALDC
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 230
MIM: 103870
HGNC: 418
Ensembl: ENSG00000109107

Variants:

dbSNP: 230
ClinVar: 230
TCGA: ENSG00000109107
COSMIC: ALDOC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109107ENST00000226253P09972
ENSG00000109107ENST00000226253A0A024QZ64
ENSG00000109107ENST00000395319A8MVZ9
ENSG00000109107ENST00000395321P09972
ENSG00000109107ENST00000395321A0A024QZ64
ENSG00000109107ENST00000435638C9J8F3
ENSG00000109107ENST00000460201J3QKP5
ENSG00000109107ENST00000578590J3QKK1
ENSG00000109107ENST00000581807K7EKH5
ENSG00000109107ENST00000584086J3KSV6

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Pentose phosphate pathwayKEGGko00030
Fructose and mannose metabolismKEGGko00051
Glycolysis / GluconeogenesisKEGGhsa00010
Pentose phosphate pathwayKEGGhsa00030
Fructose and mannose metabolismKEGGhsa00051
Metabolic pathwaysKEGGhsa01100
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGhsa_M00001
Gluconeogenesis, oxaloacetate => fructose-6PKEGGhsa_M00003
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGM00001
Gluconeogenesis, oxaloacetate => fructose-6PKEGGM00003
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glucose metabolismREACTOMER-HSA-70326
GlycolysisREACTOMER-HSA-70171
GluconeogenesisREACTOMER-HSA-70263
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
191102652009Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia.43
196860462010Redox proteomic analysis of carbonylated brain proteins in mild cognitive impairment and early Alzheimer's disease.40
194059532009Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation.38
190343802009Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis.36
203810702010Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia.22
249935272014Aldolase positively regulates of the canonical Wnt signaling pathway.17
155898422004Diverse human aldolase C gene promoter regions are required to direct specific LacZ expression in the hippocampus and Purkinje cells of transgenic mice.2
245256942014A novel anti-aldolase C antibody specifically interacts with residues 85-102 of the protein.1
303969202018Metastasis Suppressor NME1 Directly Activates Transcription of the <i>ALDOC</i> Gene in Melanoma Cells.0

Citation

Dessen P

ALDOC (aldolase, fructose-bisphosphate C)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47441/aldoc