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ALKBH1 (alkB homolog 1, histone H2A dioxygenase)

Identity

Other namesABH
ABH1
ALKBH
alkB
hABH
HGNC (Hugo) ALKBH1
LocusID (NCBI) 8846
Atlas_Id 53071
Location 14q24.3
Location_base_pair Starts at 78138749 and ends at 78174356 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
SIL1 (5q31.2) / ALKBH1 (14q24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ALKBH1   17911
Cards
Entrez_Gene (NCBI)ALKBH1  8846  alkB homolog 1, histone H2A dioxygenase
GeneCards (Weizmann)ALKBH1
Ensembl hg19 (Hinxton)ENSG00000100601 [Gene_View]  chr14:78138749-78174356 [Contig_View]  ALKBH1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000100601 [Gene_View]  chr14:78138749-78174356 [Contig_View]  ALKBH1 [Vega]
ICGC DataPortalENSG00000100601
TCGA cBioPortalALKBH1
AceView (NCBI)ALKBH1
Genatlas (Paris)ALKBH1
WikiGenes8846
SOURCE (Princeton)ALKBH1
Genomic and cartography
GoldenPath hg19 (UCSC)ALKBH1  -     chr14:78138749-78174356 -  14q24.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ALKBH1  -     14q24.3   [Description]    (hg38-Dec_2013)
EnsemblALKBH1 - 14q24.3 [CytoView hg19]  ALKBH1 - 14q24.3 [CytoView hg38]
Mapping of homologs : NCBIALKBH1 [Mapview hg19]  ALKBH1 [Mapview hg38]
OMIM605345   
Gene and transcription
Genbank (Entrez)BC015024 BC025787 BX537699 DQ890543 DQ893703
RefSeq transcript (Entrez)NM_001039506 NM_006020
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)ALKBH1
Cluster EST : UnigeneHs.94542 [ NCBI ]
CGAP (NCI)Hs.94542
Alternative Splicing : Fast-db (Paris)GSHG0009522
Alternative Splicing GalleryENSG00000100601
Gene ExpressionALKBH1 [ NCBI-GEO ]   ALKBH1 [ EBI - ARRAY_EXPRESS ]   ALKBH1 [ SEEK ]   ALKBH1 [ MEM ]
Gene Expression Viewer (FireBrowse)ALKBH1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)8846
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13686 (Uniprot)
NextProtQ13686  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13686
Splice isoforms : SwissVarQ13686 (Swissvar)
Catalytic activity : Enzyme1.14.11.33 [ Enzyme-Expasy ]   1.14.11.331.14.11.33 [ IntEnz-EBI ]   1.14.11.33 [ BRENDA ]   1.14.11.33 [ KEGG ]   
PhosPhoSitePlusQ13686
Domaine pattern : Prosite (Expaxy)FE2OG_OXY (PS51471)   
Domains : Interpro (EBI)Alkb    AlkB-like    Oxoglu/Fe-dep_dioxygenase   
Domain families : Pfam (Sanger)2OG-FeII_Oxy_2 (PF13532)   
Domain families : Pfam (NCBI)pfam13532   
DMDM Disease mutations8846
Blocks (Seattle)ALKBH1
SuperfamilyQ13686
Human Protein AtlasENSG00000100601
Peptide AtlasQ13686
IPIIPI00014482   IPI01025939   IPI01026048   
Protein Interaction databases
DIP (DOE-UCLA)Q13686
IntAct (EBI)Q13686
FunCoupENSG00000100601
BioGRIDALKBH1
STRING (EMBL)ALKBH1
ZODIACALKBH1
Ontologies - Pathways
QuickGOQ13686
Ontology : AmiGOin utero embryonic development  neuron migration  placenta development  DNA-(apurinic or apyrimidinic site) lyase activity  nuclear euchromatin  mitochondrion  DNA repair  DNA dealkylation involved in DNA repair  ferrous iron binding  regulation of gene expression  neuron projection development  chemoattractant activity  RNA repair  negative regulation of neuron apoptotic process  developmental growth  positive chemotaxis  methylcytosine dioxygenase activity  oxidative demethylation  DNA demethylation  
Ontology : EGO-EBIin utero embryonic development  neuron migration  placenta development  DNA-(apurinic or apyrimidinic site) lyase activity  nuclear euchromatin  mitochondrion  DNA repair  DNA dealkylation involved in DNA repair  ferrous iron binding  regulation of gene expression  neuron projection development  chemoattractant activity  RNA repair  negative regulation of neuron apoptotic process  developmental growth  positive chemotaxis  methylcytosine dioxygenase activity  oxidative demethylation  DNA demethylation  
NDEx Network
Atlas of Cancer Signalling NetworkALKBH1
Wikipedia pathwaysALKBH1
Orthology - Evolution
OrthoDB8846
GeneTree (enSembl)ENSG00000100601
Phylogenetic Trees/Animal Genes : TreeFamALKBH1
Homologs : HomoloGeneALKBH1
Homology/Alignments : Family Browser (UCSC)ALKBH1
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerALKBH1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALKBH1
dbVarALKBH1
ClinVarALKBH1
1000_GenomesALKBH1 
Exome Variant ServerALKBH1
ExAC (Exome Aggregation Consortium)ALKBH1 (select the gene name)
SNP (GeneSNP Utah)ALKBH1
SNP : HGBaseALKBH1
Genetic variants : HAPMAPALKBH1
Genomic Variants (DGV)ALKBH1 [DGVbeta]
Mutations
ICGC Data PortalALKBH1 
TCGA Data PortalALKBH1 
Broad Tumor PortalALKBH1
OASIS PortalALKBH1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICALKBH1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ALKBH1
DgiDB (Drug Gene Interaction Database)ALKBH1
DoCM (Curated mutations)ALKBH1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ALKBH1 (select a term)
intoGenALKBH1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)14:78138749-78174356
CONAN: Copy Number AnalysisALKBH1 
Mutations and Diseases : HGMDALKBH1
OMIM605345   
MedgenALKBH1
Genetic Testing Registry ALKBH1
NextProtQ13686 [Medical]
TSGene8846
GENETestsALKBH1
Huge Navigator ALKBH1 [HugePedia]  ALKBH1 [HugeCancerGEM]
snp3D : Map Gene to Disease8846
BioCentury BCIQALKBH1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8846
Chemical/Pharm GKB GenePA134906996
Clinical trialALKBH1
Miscellaneous
canSAR (ICR)ALKBH1 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineALKBH1
GoPubMedALKBH1
iHOPALKBH1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Apr 16 17:35:30 CEST 2016

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