ALOX15B (arachidonate 15-lipoxygenase type B)

2006-08-01  

Identity

HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
15-LOX-2
FUSION GENES

Other Information

Locus ID:

NCBI: 247
MIM: 603697
HGNC: 434
Ensembl: ENSG00000179593

Variants:

dbSNP: 247
ClinVar: 247
TCGA: ENSG00000179593
COSMIC: ALOX15B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179593ENST00000380173O15296
ENSG00000179593ENST00000380183O15296
ENSG00000179593ENST00000572022I3L1D5
ENSG00000179593ENST00000573359O15296

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Arachidonic acid metabolismKEGGko00590
Arachidonic acid metabolismKEGGhsa00590
Metabolic pathwaysKEGGhsa01100
Serotonergic synapseKEGGhsa04726
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of 15-eicosatetraenoic acid derivativesREACTOMER-HSA-2142770

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
385818592024ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2.0
385818592024ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2.0
37716021202315-lipoxygenase and cyclooxygenase expression profile and their related modulators in COVID-19 infection.1
37716021202315-lipoxygenase and cyclooxygenase expression profile and their related modulators in COVID-19 infection.1
312888082019Up-regulation of 15-lipoxygenase enzymes and products in functional and non-functional pituitary adenomas.6
314200132019Ambient fine particulate matter inhibits 15-lipoxygenases to promote lung carcinogenesis.11
312888082019Up-regulation of 15-lipoxygenase enzymes and products in functional and non-functional pituitary adenomas.6
314200132019Ambient fine particulate matter inhibits 15-lipoxygenases to promote lung carcinogenesis.11
301384232018Hypoxic cardiac fibroblasts from failing human hearts decrease cardiomyocyte beating frequency in an ALOX15 dependent manner.5
301976422018A Novel Function for 15-Lipoxygenases in Cholesterol Homeostasis and CCL17 Production in Human Macrophages.19
301384232018Hypoxic cardiac fibroblasts from failing human hearts decrease cardiomyocyte beating frequency in an ALOX15 dependent manner.5
301976422018A Novel Function for 15-Lipoxygenases in Cholesterol Homeostasis and CCL17 Production in Human Macrophages.19
288094822017Structural Dynamics of 15-Lipoxygenase-2 via Hydrogen-Deuterium Exchange.11
288094822017Structural Dynamics of 15-Lipoxygenase-2 via Hydrogen-Deuterium Exchange.11
269189372016Understanding the Mechanism of the Hydrogen Abstraction from Arachidonic Acid Catalyzed by the Human Enzyme 15-Lipoxygenase-2. A Quantum Mechanics/Molecular Mechanics Free Energy Simulation.13

Citation

Dessen P

ALOX15B (arachidonate 15-lipoxygenase type B)

Atlas Genet Cytogenet Oncol Haematol. 2006-08-01

Online version: http://atlasgeneticsoncology.org/gene/42987/alox15b