ALOX15B (arachidonate 15-lipoxygenase type B)

2006-08-01  

Identity

HGNC
ALOX15B
LOCATION
17p13.1
LOCUSID
247
ALIAS
15-LOX-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 247
MIM: 603697
HGNC: 434
Ensembl: ENSG00000179593

Variants:

dbSNP: 247
ClinVar: 247
TCGA: ENSG00000179593
COSMIC: ALOX15B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179593ENST00000380173O15296
ENSG00000179593ENST00000380183O15296
ENSG00000179593ENST00000572022I3L1D5
ENSG00000179593ENST00000573359O15296

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Arachidonic acid metabolismKEGGko00590
Arachidonic acid metabolismKEGGhsa00590
Metabolic pathwaysKEGGhsa01100
Serotonergic synapseKEGGhsa04726
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of 15-eicosatetraenoic acid derivativesREACTOMER-HSA-2142770

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
219003942011Tumor-associated macrophages mediate immunosuppression in the renal cancer microenvironment by activating the 15-lipoxygenase-2 pathway.54
165564932006Reduction of isoforms of 15-lipoxygenase (15-LOX)-1 and 15-LOX-2 in human breast cancer.38
118397512002Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells.32
244976442014The structure of human 15-lipoxygenase-2 with a substrate mimic.27
127041952003Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants.26
21316676201112- and 15-lipoxygenases in human carotid atherosclerotic lesions: associations with cerebrovascular symptoms.22
194235402009Common variation in genes related to innate immunity and risk of adult glioma.19
157998282005Inverse relationship between 15-lipoxygenase-2 and PPAR-gamma gene expression in normal epithelia compared with tumor epithelia.17
229805002012Expression and regulation of 12/15-lipoxygenases in human primary macrophages.17
196454542009Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2.16

Citation

Dessen P

ALOX15B (arachidonate 15-lipoxygenase type B)

Atlas Genet Cytogenet Oncol Haematol. 2006-08-01

Online version: http://atlasgeneticsoncology.org/gene/42987/alox15b